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Showing 1–3 of 3 results
Advanced filters: Author: Jin-Mi Heo Clear advanced filters

  • The activity of translation initiation factor eIF2B is known to be modulated through stress-responsive phosphorylation of its substrate eIF2. Here, the authors uncover the regulation of eIF2B by the binding of sugar phosphates, suggesting a link between nutrient status and the rate of protein synthesis.

    • Qi Hao
    • Jin-Mi Heo
    • Carmela Sidrauski
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-12

  • ISR-specific contributions to stress-induced cellular outputs are not well understood. Here,

    authors use a minimal activation system and multi-omics to define an ISR-sufficient metabolic state that includes protective accumulation of lipid droplets.

    • Katherine Labbé
    • Lauren LeBon
    • Carmela Sidrauski
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-21

  • Recent studies that combine cell biology, structural and proteomic approaches have unravelled how ubiquitin is conjugated to damaged mitochondria through the PINK1–parkin pathway to promote mitophagy. The findings have revealed links between PINK1–parkin, antigen presentation and neuronal survival and have implications for the understanding of neurological disorders.

    • J. Wade Harper
    • Alban Ordureau
    • Jin-Mi Heo
    Reviews
    Nature Reviews Molecular Cell Biology
    Volume: 19, P: 93-108