Advanced search

Filter By:

Journal Check one or more journals to show results from those journals only.

Choose more journals

Article type Check one or more article types to show results from those article types only.
Subject Check one or more subjects to show results from those subjects only.
Date Choose a date option to show results from those dates only.

Custom date range

Clear all filters
Sort by:
Showing 1–3 of 3 results
Advanced filters: Author: Jinbae Son Clear advanced filters

  • Acquired resistance limits the efficacy of PARP inhibitors (PARPi) in high grade serous ovarian cancer (HGSOC). Here, the authors show that inhibition of RNA polymerase I transcription using CX-5461 increases the therapeutic efficacy of PARPi and overcomes PARPi resistance in PDX models of HGSOC.

    • Elaine Sanij
    • Katherine M. Hannan
    • Richard B. Pearson
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-18

  • Increasing evidence indicates that intratumoural bacteria can have crucial roles in both the pathogenesis and treatment of cancer. In this Review, the authors discuss the characteristics of intratumoural bacteria and the emerging understanding of their tumour-promoting and antitumour activities. They also describe a range of innovative strategies that are being used to engineer bacteria for use in the treatment of cancer and summarize clinical trials of various bacteria-mediated cancer immunotherapies.

    • Seong-Young Kwon
    • Hien Thi-Thu Ngo
    • Jung-Joon Min
    Reviews
    Nature Reviews Clinical Oncology
    Volume: 21, P: 569-589

  • Jeannine Diesch et al. report the changes in rDNA chromatin state associated with cell transition into malignancy. They show that a specific transcription factor regulates this transition by altering rDNA chromatin, resulting in the reorganization of contacts between rDNA and the genome.

    • Jeannine Diesch
    • Megan J. Bywater
    • Gretchen Poortinga
    ResearchOpen Access
    Communications Biology
    Volume: 2, P: 1-14