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Showing 1–7 of 7 results
Advanced filters: Author: Jingji Zhang Clear advanced filters

  • Initiation of HIV-1 reverse transcription occurs at the host tRNALys3, which forms a complex with the 5’ end of the HIV-1 viral RNA and reverse transcriptase (RT). Here, the authors present the 2.8 Å cryo-EM structure of a minimal HIV-1 RT–vRNA–tRNALys3 initiation complex (miniRTIC), and miniRTIC structures with the bound non-nucleoside reverse transcriptase inhibitors nevirapine and efavirenz at 3.1 and 2.9 Å resolution, respectively.

    • Betty Ha
    • Kevin P. Larsen
    • Elisabetta Viani Puglisi
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-11

  • Single-molecule FRET technologies reveal the mechanism of sequence-specific translational inhibition induced by two antibiotics, chloramphenicol and linezolid, where aminoacyl-tRNA was repeatedly rejected from the A-site and failed to form a peptide bond.

    • Junhong Choi
    • James Marks
    • Joseph D. Puglisi
    Research
    Nature Chemical Biology
    Volume: 16, P: 310-317

  • The authors use optogenetics to selectively activate single glomeruli in behaving mice. They find that mice can perceive the stimulation of a single glomerulus, even on an intense odor background. Different input intensities and the timing of input relative to sniffing can also be discriminated. This suggests that each glomerulus can transmit odor information using identity, intensity and temporal coding cues.

    • Matthew Smear
    • Admir Resulaj
    • Dmitry Rinberg
    Research
    Nature Neuroscience
    Volume: 16, P: 1687-1691

  • Odorous chemicals broadly activate subsets of olfactory receptors in the nose, but how individual receptors contribute to behavioral sensitivity is not clear. Here, the authors demonstrate that detection thresholds in mice are set solely by the highest affinity receptor for a given odorant.

    • Adam Dewan
    • Annika Cichy
    • Thomas Bozza
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-12

  • Mitral/tufted (MT) cells connect to a single glomerulus and receive inputs from sensory neurons expressing the same odorant receptor. Here the authors report that sister MT cells connected to the M72 glomerulus exhibit variable responses to most M72 ligands but respond in a reproducible and stereotyped way to a high-affinity M72 ligand.

    • Ezequiel M. Arneodo
    • Kristina B. Penikis
    • Dmitry Rinberg
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-13

  • Nanostructures are observed in many areas of materials science, and are often loosely described based on their shape. Here, a framework is presented for the categorization of nanoparticles based on their statistically defined geometry.

    • Luca Boselli
    • Hender Lopez
    • Kenneth A. Dawson
    ResearchOpen Access
    Communications Materials
    Volume: 1, P: 1-12