Idelalisib, a specific inhibitor of phosphoinositide 3-kinase (PI3K) δ, inhibits Akt activation, fibronectin expression and collagen gel contraction induced by transforming growth factor (TGF)-β2 in human RPE cells as well as in an animal model of proliferative vitroretinopathy. These results suggest that idelalisib may be useful for preventing proliferative vitroretinopathy in humans.
- Lijun Dong
- Haote Han
- Hetian Lei
