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Advanced filters: Author: Jingrui Priscilla Wang Clear advanced filters

  • Through directed evolution, the PAM compatibility of the compact Cas9 variant CjCas9 was increased. Evolved CjCas9 shows higher nuclease activity at canonical and non-canonical sites and enables robust in vivo gene editing from single AAV vectors.

    • Lukas Schmidheini
    • Nicolas Mathis
    • Gerald Schwank
    Research
    Nature Chemical Biology
    Volume: 20, P: 333-343