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Showing 1–4 of 4 results
Advanced filters: Author: Jinta Asami Clear advanced filters

  • In this study, Asami et al. present the cryo-EM structure of the complex between hepatitis B virus protein and its host entry receptor NTCP, which provide a blueprint for the rational design of anti-HBV drugs targeting virus entry.

    • Jinta Asami
    • Jae-Hyun Park
    • Umeharu Ohto
    Research
    Nature Structural & Molecular Biology
    Volume: 31, P: 447-454

  • LGR4, RSPO and ZNRF3 are key regulators of the Wnt/β-catenin signaling pathway. Here, the authors reveal cryo-EM structures of human LGR4, the LGR4-RSPO2 and LGR4-RSPO2-ZNRF3 complexes, thereby providing structural insights for their regulatory mechanism of Wnt/β-catenin signaling.

    • Yuxuan Peng
    • Akiko Fujimura
    • Umeharu Ohto
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-10

  • Cryo-electron microscopy structures of the bile acid transporter NTCP in the apo state and in complex with the preS1 domain of hepatitis B virus (HBV) provide insight into NTCP substrate transport and HBV recognition mechanisms.

    • Jinta Asami
    • Kanako Terakado Kimura
    • Umeharu Ohto
    Research
    Nature
    Volume: 606, P: 1021-1026

  • Cryo-EM structures of nucleic acid–sensing Toll-like receptors in complex with their trafficking chaperone UNC93B1, a protein that mediates TLR compartmentalization important for self versus non-self discrimination, provide insights into their interaction.

    • Hanako Ishida
    • Jinta Asami
    • Toshiyuki Shimizu
    Research
    Nature Structural & Molecular Biology
    Volume: 28, P: 173-180