How repair of DNA interstrand crosslinks contributes to mutagenesis is not understood. Here, the authors identify two mutagenic repair pathways in C. elegans: FAN1-mediated translesion synthesis causing SNVs, and POLQ-mediated end joining leading to deletions. They also uncover a role for TRAIP.
- Jip Verschuren
- Robin van Schendel
- Marcel Tijsterman
