Nature Search

Left-handed DNA for efficient highly multiplexed imaging at single-protein resolution

By combining left- and right-handed DNA-PAINT probes, Unterauer et al. achieve simple, robust, and highly multiplexed super-resolution. They show 13-plex neuronal maps, revealing nanoscale organization of cytoskeleton, organelles, and synapses.

Eduard M. Unterauer
Eva-Maria Schentarra
Ralf Jungmann
ResearchOpen Access02 Oct 2025
Nature Communications

Volume: 16, P: 1-8
Resolving the structural basis of therapeutic antibody function in cancer immunotherapy with RESI

The nanoscale organization of the antigen-antibody complexes influences the therapeutic action of monoclonal antibodies. Here, the authors present a multi-target 3D RESI imaging assay for the nanometer spatial analysis of CD20 in complex with therapeutic monoclonal antibodies within intact cells, to analyse the interdependency between the mode of antibody binding and the therapeutic function.

Isabelle Pachmayr
Luciano A. Masullo
Ralf Jungmann
ResearchOpen Access23 Jul 2025
Nature Communications

Volume: 16, P: 1-13
Spatial and stoichiometric in situ analysis of biomolecular oligomerization at single-protein resolution

Extracting quantitative information on biomolecular oligomerisation with high resolution remains a significant challenge. Here, the authors propose SPINNA, a framework that compares nearest-neighbour distances from experimental single-protein position data with those obtained from simulations based on a model of protein oligomerisation.

Luciano A. Masullo
Rafal Kowalewski
Ralf Jungmann
ResearchOpen Access06 May 2025
Nature Communications

Volume: 16, P: 1-11
Combined IgE neutralization and Bifidobacterium longum supplementation reduces the allergic response in models of food allergy

IgE is a critical component of the allergic response and therapeutic targeting can alleviate symptomology. Here the authors propose the combined use of Bifidobacterium longum and a FcεRIα extracellular domain linked to a IgD/IgG4 hybrid Fc domain fusion protein called IgE_TRAP and show reduction of mast cell and IgE levels in models of food allergy.

Seong Beom An
Bo-Gie Yang
Myoung Ho Jang
ResearchOpen Access27 Sept 2022
Nature Communications

Volume: 13, P: 1-16
Deep learning approach for dysphagia detection by syllable-based speech analysis with daily conversations

Seokhyeon Heo
Kyeong Eun Uhm
Jongmin Lee
ResearchOpen Access31 Aug 2024
Scientific Reports

Volume: 14, P: 1-9
Mitochondrial aconitase suppresses immunity by modulating oxaloacetate and the mitochondrial unfolded protein response

Mitochondrial function has been linked to immunity but the role of the Krebs’s cycle in regards the immune response is not well characterised. Here the authors show that Krebs’s cycle enzyme ACO2 suppresses immunity via modulation of oxaloacetate and the mitochondrial unfolded protein response.

Eunah Kim
Andrea Annibal
Seung-Jae V. Lee
ResearchOpen Access22 Jun 2023
Nature Communications

Volume: 14, P: 1-16
Publisher Correction: Alleviation of preeclampsia-like symptoms through PlGF and eNOS regulation by hypoxia- and NF-κB-responsive miR-214-3p deletion

Suji Kim
Sungbo Shim
Young-Myeong Kim
Amendments and CorrectionsOpen Access18 Jul 2024
Experimental & Molecular Medicine

Volume: 56, P: 1682
Slow oxidation of magnetite nanoparticles elucidates the limits of the Verwey transition

The Verwey transition in magnetite has been studied for nearly eight decades since its discovery in the 1940s. Here, Kim et al. elucidate the influence of chemical doping by extremely slow oxidization process with magnetite nanoparticles, revealing why first- and second-order regimes of the Verwey transition are observed.

Taehun Kim
Sangwoo Sim
Je-Geun Park
ResearchOpen Access04 Nov 2021
Nature Communications

Volume: 12, P: 1-6
The DNA-PAINT palette: a comprehensive performance analysis of fluorescent dyes

The dyes chosen for DNA-PAINT microscopy are pivotal for data quality. This Analysis shows a comprehensive comparison of 18 fluorescent dyes in DNA-PAINT and offers guidance for optimum dye selection in single-color and multiplexed imaging.

Philipp R. Steen
Eduard M. Unterauer
Ralf Jungmann
ResearchOpen Access07 Aug 2024
Nature Methods

Volume: 21, P: 1755-1762
Alleviation of preeclampsia-like symptoms through PlGF and eNOS regulation by hypoxia- and NF-κB-responsive miR-214-3p deletion

Suji Kim
Sungbo Shim
Young-Myeong Kim
ResearchOpen Access03 Jun 2024
Experimental & Molecular Medicine

Volume: 56, P: 1388-1400
Long-term Intracellular Recording of Optogenetically-induced Electrical Activities using Vertical Nanowire Multi Electrode Array

Jisoo Yoo
Hankyul Kwak
Heon-Jin Choi
ResearchOpen Access09 Mar 2020
Scientific Reports

Volume: 10, P: 1-10
Author Correction: Pharmacological inhibition of mTOR attenuates replicative cell senescence and improves cellular function via regulating the STAT3-PIM1 axis in human cardiac progenitor cells

Ji Hye Park
Na Kyoung Lee
Sang-Mo Kwon
Amendments and CorrectionsOpen Access27 Nov 2023
Experimental & Molecular Medicine

Volume: 55, P: 2473
Author Correction: Human cardiac stem cells rejuvenated by modulating autophagy with MHY-1685 enhance the therapeutic potential for cardiac repair

Ji Hye Park
Hyeok Kim
Sang-Mo Kwon
Amendments and CorrectionsOpen Access26 Jul 2022
Experimental & Molecular Medicine

Volume: 54, P: 1061-1063
Nonclassical nucleation and growth of inorganic nanoparticles

To optimize the synthesis of functionally designed nanoparticles, a clear understanding of their formation mechanisms is needed. This Review presents the structural properties of nanoclusters and their role in the prenucleation period, and discusses nonclassical nucleation and growth models, as well as heterogeneous nucleation of multicomponent nanoparticles.

Jisoo Lee
Jiwoong Yang
Taeghwan Hyeon
Reviews01 Jun 2016
Nature Reviews Materials

Volume: 1, P: 1-16
Human cardiac stem cells rejuvenated by modulating autophagy with MHY-1685 enhance the therapeutic potential for cardiac repair

Ji Hye Park
Hyeok Kim
Sang-Mo Kwon
ResearchOpen Access28 Sept 2021
Experimental & Molecular Medicine

Volume: 53, P: 1423-1436
Yin Yang 1 is required for PHD finger protein 20-mediated myogenic differentiation in vitro and in vivo

Hyunji Lee
Youngeun Hong
Jisoo Park
Research18 Jun 2020
Cell Death & Differentiation

Volume: 27, P: 3321-3336
Pharmacological inhibition of mTOR attenuates replicative cell senescence and improves cellular function via regulating the STAT3-PIM1 axis in human cardiac progenitor cells

Ji Hye Park
Na Kyoung Lee
Sang-Mo Kwon
ResearchOpen Access09 Apr 2020
Experimental & Molecular Medicine

Volume: 52, P: 615-628

Search

Left-handed DNA for efficient highly multiplexed imaging at single-protein resolution

Resolving the structural basis of therapeutic antibody function in cancer immunotherapy with RESI

Spatial and stoichiometric in situ analysis of biomolecular oligomerization at single-protein resolution

Combined IgE neutralization and Bifidobacterium longum supplementation reduces the allergic response in models of food allergy

Deep learning approach for dysphagia detection by syllable-based speech analysis with daily conversations

Mitochondrial aconitase suppresses immunity by modulating oxaloacetate and the mitochondrial unfolded protein response

Publisher Correction: Alleviation of preeclampsia-like symptoms through PlGF and eNOS regulation by hypoxia- and NF-κB-responsive miR-214-3p deletion

Slow oxidation of magnetite nanoparticles elucidates the limits of the Verwey transition

The DNA-PAINT palette: a comprehensive performance analysis of fluorescent dyes

Alleviation of preeclampsia-like symptoms through PlGF and eNOS regulation by hypoxia- and NF-κB-responsive miR-214-3p deletion

Long-term Intracellular Recording of Optogenetically-induced Electrical Activities using Vertical Nanowire Multi Electrode Array

Author Correction: Pharmacological inhibition of mTOR attenuates replicative cell senescence and improves cellular function via regulating the STAT3-PIM1 axis in human cardiac progenitor cells

Author Correction: Human cardiac stem cells rejuvenated by modulating autophagy with MHY-1685 enhance the therapeutic potential for cardiac repair

Nonclassical nucleation and growth of inorganic nanoparticles

Human cardiac stem cells rejuvenated by modulating autophagy with MHY-1685 enhance the therapeutic potential for cardiac repair

Yin Yang 1 is required for PHD finger protein 20-mediated myogenic differentiation in vitro and in vivo

Pharmacological inhibition of mTOR attenuates replicative cell senescence and improves cellular function via regulating the STAT3-PIM1 axis in human cardiac progenitor cells

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