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Showing 1–3 of 3 results
Advanced filters: Author: Jiufu Qin Clear advanced filters

  • The complexity of yeast amino acid metabolism has limited carbon channelling to produce valuable chemical metabolites. Here, the authors implement a yeast customized pathway optimization strategy and demonstrate its use for overproduction of L-ornithine, an intermediate of L-arginine biosynthesis.

    • Jiufu Qin
    • Yongjin J. Zhou
    • Jens Nielsen
    ResearchOpen Access
    Nature Communications
    Volume: 6, P: 1-11

  • While yeast is an attractive alternative to bacteria for the production of biofuels it currently has low production yields. Here, the authors systematically engineer Saccharomyces cerevisiae for high-level production of fatty acids, alkanes and fatty alcohols, which are important fuel precursors.

    • Yongjin J. Zhou
    • Nicolaas A. Buijs
    • Jens Nielsen
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-9

  • Structurally complex polyamines and polyamine analogues show potential as therapeutics and agrochemicals, but their production remains hampered. Here a polyamine yeast cell factory is developed that enables the gram-per-litre-scale titres of spermidine and the complete biosynthesis of a broad set of these compounds.

    • Jiufu Qin
    • Anastasia Krivoruchko
    • Jens Nielsen
    Research
    Nature Catalysis
    Volume: 4, P: 498-509