The generation of neoantigen-specific T cells for adoptive cell therapy (ACT) is challenging. Here the authors conveniently produce ACT-amenable neoantigen-reactive T cells (NRT) by inducing neoantigen-specific immune responses in vivo via dendritic cell vaccination and find adoptive transfer of such NRTs in a pre-immunized mouse model of lung cancer improves ACT efficacy and induces tumor regression.
- Qing Li
- Hao Zeng
- Zhenyu Ding
