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Showing 1–3 of 3 results
Advanced filters: Author: Jiwu Ren Clear advanced filters

  • RNA circularization is vital for circRNA therapeutics. Here, authors present two in vitro methods—PIET and CIRC—where CIRC employs intact self-splicing introns to generate circRNAs efficiently, and enables large circRNA generation, broadening the circRNA platform’s potential.

    • Yong Shen
    • Bohan Li
    • Wensheng Wei
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-15

  • Base editing technologies predominantly utilize engineered deaminases for cytosine and adenine. Here, the authors achieve efficient, specific, and low-toxicity base editing of thymine by engineering Deinococcus radiodurans uracil-DNA glycosylase.

    • Zongyi Yi
    • Xiaoxue Zhang
    • Wensheng Wei
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-10