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Aluminum has been considered a promising alloy-type negative electrode for all-solid-state batteries. Here, the authors introduce a comprehensive study of β-LiAl phase-dependent Li⁺ kinetics and microstructural evolution, leading to the demonstration of an optimized high-loading Li-Al-based cell.

Systematic analysis from the Global Burden of Disease study reported that, despite global improvements from 1990 to 2021, dietary iron deficiency-associated disease burden remains high in women, children and residents in low socio-demographic index countries.

Upon cold exposure, two types of thermogenic fat cells, brown and beige adipocytes, are sequentially activated. Here, the authors show that E3 ubiquitin ligase RNF20 coordinates the sequential thermogenic activation through fat depot specific substrates.

All-solid-state batteries face practical challenges such as sustainable fabrication and low-stack pressure operation. Here, authors develop a modified dry-process technique to yield robust solid electrolyte-electrode interface for practical fabrication and operation of all-solid-state batteries.

Despite hyperglycemia has been associated to breast cancer, the underlying mechanisms are not completely understood. Here, the authors show that epigenetic regulation of Nrg1 gene during hyperglycemia promotes breast cancer development.

The authors use fMRI in rats to show that covert sensory input influences the dynamics of resting state brain activity. This indicates a mechanism by which the environment shapes neural function even in the absence of explicit stimuli or tasks.

Park et al. shed light on the dynamics of DNA demethylation during adipocyte differentiation, which is shown to be regulated by the transcription factor C/EBPδ and the DNA methylation eraser TET3.

It is desirable to develop fast-charging batteries retaining high energy density. Here, the authors report a hybrid anode via incorporation of an implanted amorphous silicon nanolayer and edge-plane-activated graphite, which meets both criteria.

The few options available for the measurement of in-plane and cross-plane thermal conductivity of covalent organic frameworks films limit their application for lightweight thermal management. Here, the authors measure both, the in-plane and cross-plane thermal conductivity of two dimensional covalent organic frameworks with different pore sizes using laser-based pump-probe techniques.

Apart from the enzymatic role of ketohexokinase isoform A (KHK-A) in fructose metabolism the alternative physiological functions of the enzyme are unclear. Here, the authors show that KHK-A mediates fructose-induced metastasis in breast cancer through a nuclear role in repressing the transcriptional activity of the cell-adhesion molecule CDH1.

In vivo laser ablation of dendrites in single L2/3 pyramidal neurons reveals that neuronal orientation tuning in V1 is robust to loss of dendritic input. Orientation tuning functions remain unchanged following apical dendrite ablation and change only slightly upon loss of two primary basal dendrites.

Here the authors show a pore-coordinated rational design to enable a Si hybrid anode that exhibits minimized electrode swelling comparable to conventional graphite and therefore high volumetric capacity and energy density.

The adipokine endotrophin promotes tumour inflammation and angiogenesis, but its effects on adipose tissue are unclear. Here, Sun et al.show that endotrophin promotes adipose tissue inflammation and fibrosis, and that injections of an anti-endotrophin antibody improve metabolic parameters of mice on a high-fat diet.

Palmitoylation of proteins can have pathophysiological implications. Here, the authors show that palmitoylation enhances the proteasomal degradation of the histone demethylase PHF2, leading to increased lipogenesis and cell proliferation in an SREBP1c dependent manner and further show that PHF2 acts as an E3 ligase of SREBP1c, suppressing the growth of liver cancer cells.

Maintaining the structural stability during electrochemical cycling remains a big challenge facing the silicon anode material. Here, the authors have developed 2D silicon nanosheets coated with carbon layers, which show a unique mechanism in releasing internal stress by forming ripple structures.

Mice overexpressing the mitochondrial protein MitoNEET in white adipose tissue (WAT) are very fat but metabolically healthy. Here the authors study the physiological consequences of MitoNEET overexpression in WAT, showing that this triggers an initial browning and that the subsequently expanded WAT is less fibrotic.

Double-sided epitaxy of van der Waals materials through atomic membranes is demonstrated, enabling electrons to resonantly tunnel between aligned topological insulator surfaces with the conservation of energy, momentum and spin helicity.

Subtyping of non-small cell lung cancer can be challenging based on pathology. Here, the authors utilise multi-omics analysis of 229 patients to identify further subtypes, and altered immune composition between subtypes.

NF-κB activation contributes to colitis-associated colorectal cancer (CAC). Here the authors show that NF-κB subunit, p65 stabilizes ITF2, which then suppresses NF-κB downstream genes and inhibits CAC progression.

Our understanding of the development of the heart has been limited by a lack of in vitro cellular models. Here, the authors treat mouse embryonic stem cell-derived embryoid bodies with laminin-entactin (to mimic the developing microenvironment) and FGF4 to form heart organoids, with atrial and ventricular-like parts.

Activation of thermogenic beige adipocytes within white adipose tissue increases energy expenditure. Here, the authors show that expression of TonEBP in adipocytes is increased when mice are fed a high fat diet and that it suppresses expression of beta3-adrenoreceptor.

Extensive research efforts have been directed towards the development of PET hydrolases with improved activity, but template enzymes used are limited. Here, the authors report a PET hydrolase from Cryptosporangium aurantiacum (CaPETase) that exhibits high thermostability and PET degradation activity at ambient temperatures and determine its crystal structure.

Reactive oxygen species management is a practical strategy that can reduce the risk of chemotherapy-induced acute kidney injury, but at the cost of chemotherapeutic efficacy. Here the authors report catalytic activity tunable ceria nanoparticles as context-dependent reactive oxygen species scavengers, which can prevent chemotherapy-induced acute kidney injury without interfering with chemotherapeutic agents.

BTLA is established as a negative regulator of natural killer T (NKT) cell function, and share its ligand HVEM with CD160. Here the authors show, by analyzing NKT activation in CD160-deficient mice or with BTLA blockade, that CD160 synergizes with BTLA to negatively regulate NKT cells during hepatic injury.

Silicon-based anodes are a promising alternative to the graphite anodes that are widely used in today’s commercial batteries. Here the authors report a synthesis route for silicon anodes consisting of subnanometre-sized particles and demonstrate their use in an unusual large-scale battery pack system.

Electrons can behave as if they are at a temperature different from that of the solid in which they are embedded. Here, the authors demonstrate a room temperature device that can generate electrons with an effective temperature of 45 K by using quantum wells to filter out energetic particles.

Silicon has long been recognized as a high-energy battery electrode but its commercialization faces significant barriers. Here the authors report scalable synthesis of silicon-nanolayer-embedded graphite electrodes that display cycling stability at the industrial electrode density.

Protein-actuated clustering of magnetic nanoparticles enables MRI-based measurement of extracellular calcium ion dynamics in the living rodent brain.