Mechanisms underlying partial functional recovery after spinal cord injury are unclear. Conditionally knocking out the reinduced repulsive axon guidance receptor Ryk led to increased corticospinal axon plasticity and functional recovery. Motor cortex reorganized such that the hindlimb cortex controls the forelimb with continued forelimb reaching task training. A greater cortical area was recruited to control the forelimb in Ryk cKO.
- Edmund R Hollis II
- Nao Ishiko
- Yimin Zou
