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Showing 1–3 of 3 results
Advanced filters: Author: Joachim Ellwart Clear advanced filters

  • The tissues of the central nervous system are shielded from the blood circulation by specialized vessels, impermeable to cells and most circulating macromolecules. Despite this, central nervous system tissues are subject to immune surveillance and are vulnerable to autoimmune attack. Here, intravital two-photon imaging is used to observe, in real-time, the interactive processes between effector T cells and cerebral structures leading to an experimental rat model of autoimmune encephalitis.

    • Ingo Bartholomäus
    • Naoto Kawakami
    • Alexander Flügel
    Research
    Nature
    Volume: 462, P: 94-98

  • A Lewis rat model of experimental autoimmune encephalomyelitis is used to show that on their way to the CNS, encephalitogenic T-cell blasts are temporarily resident in the lung, where they reprogram their gene-expression profile and functional properties to enable them to transgress the blood–brain barrier into the CNS.

    • Francesca Odoardi
    • Christopher Sie
    • Alexander Flügel
    Research
    Nature
    Volume: 488, P: 675-679