Nature Search

Author Correction: Whole genome sequencing of metastatic colorectal cancer reveals prior treatment effects and specific metastasis features

Pauline A. J. Mendelaar
Marcel Smid
Saskia M. Wilting
Amendments and CorrectionsOpen Access26 May 2021
Nature Communications

Volume: 12, P: 1
The genomic landscape of 85 advanced neuroendocrine neoplasms reveals subtype-heterogeneity and potential therapeutic targets

Metastatic and locally-advanced neuroendocrine neoplasms (aNEN) display heterogeneous clinical and genetic characteristics. Here, the authors investigate the mutational landscape of 85 aNEN by whole genome sequencing and identify distinct subpopulations, tumour mutational burden patterns, drivers and actionable somatic alterations.

Job van Riet
Harmen J. G. van de Werken
Bianca Mostert
ResearchOpen Access29 Jul 2021
Nature Communications

Volume: 12, P: 1-14
The genomic landscape of metastatic castration-resistant prostate cancers reveals multiple distinct genotypes with potential clinical impact

Detecting genomic abnormalities in metastatic castration-resistant prostate cancer (mCRPC) may impact clinical treatment. Here, the authors present whole-genome sequencing of metastatic biopsies from 197 mCRPC patients, highlighting the landscape of microsatellite stability, homologous repair deficiency, and other genomic subgroups.

Lisanne F. van Dessel
Job van Riet
Martijn P. Lolkema
ResearchOpen Access20 Nov 2019
Nature Communications

Volume: 10, P: 1-13
Four Core Genotypes mice harbour a 3.2MB X-Y translocation that perturbs Tlr7 dosage

Here the authors find a genetic alteration in the popular “Four Core Genotypes” mouse model that is used to distinguish sex-biased phenotypes caused by sex chromosomes and gonads. This alteration increases the expression of some X-linked genes, which might confound the interpretation of the model.

Jasper Panten
Stefania Del Prete
Duncan T. Odom
ResearchOpen Access11 Oct 2024
Nature Communications

Volume: 15, P: 1-8
Whole genome sequencing of metastatic colorectal cancer reveals prior treatment effects and specific metastasis features

Molecular landscapes of metastatic colorectal cancers (mCRC) have often been restricted to coding regions or low numbers of patients. Here the authors present a whole-genome landscape of 429 mCRC patients, revealing the mutational impact of prior therapies and potential actionable targets.

Pauline A. J. Mendelaar
Marcel Smid
Saskia M. Wilting
ResearchOpen Access25 Jan 2021
Nature Communications

Volume: 12, P: 1-11
The genomic landscape of metastatic breast cancer highlights changes in mutation and signature frequencies

Whole-genome sequencing of metastatic biopsies from 442 patients with breast cancer provides insights into metastatic disease, including associations of genomic features with prior treatments and identification of therapeutic vulnerabilities.

Lindsay Angus
Marcel Smid
John W. M. Martens
Research30 Sept 2019
Nature Genetics

Volume: 51, P: 1450-1458
Predicting response to enzalutamide and abiraterone in metastatic prostate cancer using whole-omics machine learning

Prostate cancer is known to have a variable response to androgen receptor signalling inhibitors. Here, the authors use machine learning to predict response to therapy from genomic, transcriptomic and clinical data.

Anouk C. de Jong
Alexandra Danyi
Martijn P. Lolkema
ResearchOpen Access08 Apr 2023
Nature Communications

Volume: 14, P: 1-19
CRISPRs in the human genome are differentially expressed between malignant and normal adjacent to tumor tissue

CRISPR elements in the human genome are expressed in both healthy tissues and tumors but with distinct patterns, representing a potential biomarker for cancer.

Job van Riet
Chinmoy Saha
Rogier Louwen
ResearchOpen Access08 Apr 2022
Communications Biology

Volume: 5, P: 1-13
Molecular heterogeneity and early metastatic clone selection in testicular germ cell cancer development

Lambert C. J. Dorssers
Ad J. M. Gillis
Leendert H. J. Looijenga
ResearchOpen Access11 Feb 2019
British Journal of Cancer

Volume: 120, P: 444-452

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Author Correction: Whole genome sequencing of metastatic colorectal cancer reveals prior treatment effects and specific metastasis features

The genomic landscape of 85 advanced neuroendocrine neoplasms reveals subtype-heterogeneity and potential therapeutic targets

The genomic landscape of metastatic castration-resistant prostate cancers reveals multiple distinct genotypes with potential clinical impact

Four Core Genotypes mice harbour a 3.2MB X-Y translocation that perturbs Tlr7 dosage

Whole genome sequencing of metastatic colorectal cancer reveals prior treatment effects and specific metastasis features

The genomic landscape of metastatic breast cancer highlights changes in mutation and signature frequencies

Predicting response to enzalutamide and abiraterone in metastatic prostate cancer using whole-omics machine learning

CRISPRs in the human genome are differentially expressed between malignant and normal adjacent to tumor tissue

Molecular heterogeneity and early metastatic clone selection in testicular germ cell cancer development

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