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Epigenetic control of FOXP3 expression: the key to a stable regulatory T-cell lineage?

Regulatory T (T_Reg) cells are crucial for immune homeostasis, and manipulation of their suppressive functions is a possible avenue for immunotherapy. Here, the authors discuss recent advances in our understanding of how the expression of forkhead box P3 (FOXP3), a T_Reg-cell-specifying transcription factor, is controlled at the molecular level.

Jochen Huehn
Julia K. Polansky
Alf Hamann
Reviews01 Feb 2009
Nature Reviews Immunology

Volume: 9, P: 83-89
Postnatal expansion of mesenteric lymph node stromal cells towards reticular and CD34⁺ stromal cell subsets

Lymph nodes in various locations of the body differ in their cell composition and gene expression signatures. Here authors show that the rapid postnatal expansion of lymph nodes is governed by CD34 ⁺ stromal cells and fibroblastic reticular stromal cell progenitors, distinguished by intrinsic, microbiome-independent core epigenetic blueprints.

Joern Pezoldt
Carolin Wiechers
Jochen Huehn
ResearchOpen Access24 Nov 2022
Nature Communications

Volume: 13, P: 1-19
Epigenetic orchestration of thymic T_reg cell development

Regulatory T cells develop in the thymus as a distinct lineage of T cells instructed by the lineage-specifying transcription factor Foxp3. Epigenetic imprinting by the genome organizer Satb1 precedes this cell-fate 'decision' during thymocyte development.

Marc Beyer
Jochen Huehn
News & Views19 Jan 2017
Nature Immunology

Volume: 18, P: 144-146
Erratum: De novo fatty acid synthesis controls the fate between regulatory T and T helper 17 cells

Luciana Berod
Christin Friedrich
Tim Sparwasser
Amendments and Corrections07 Apr 2015
Nature Medicine

Volume: 21, P: 414
DNA hypomethylation traits define human regulatory T cells in cutaneous tissue and identify their blood recirculating counterparts

Feuerer and colleagues use multiomic analyses to identify DNA methylation, chromatin accessibility and gene expression programs that govern the tissue adaptation of human skin T_reg cells.

Niklas Beumer
Charles D. Imbusch
Markus Feuerer
ResearchOpen Access16 Jul 2025
Nature Immunology

Volume: 26, P: 1315-1328
Neonatally imprinted stromal cell subsets induce tolerogenic dendritic cells in mesenteric lymph nodes

Induction of tolerance in the gut relies on immunomodulatory functions of mesenteric lymph nodes (mLN). Here the authors show that mLN stromal cells receive early microbiota imprinting in the neonatal phase to exhibit long-term, location-specific transcriptional programs for the induction of regulatory T cells and peripheral tolerance.

Joern Pezoldt
Maria Pasztoi
Jochen Huehn
ResearchOpen Access25 Sept 2018
Nature Communications

Volume: 9, P: 1-14
A comprehensive genetic map of cytokine responses in Lyme borreliosis

Common genetic variants can affect an individual’s immune response to pathogens. Here, the authors uncover and characterize variants regulating cytokine responses in Lyme Borreliosis in 1,060 patients.

Javier Botey-Bataller
Hedwig D. Vrijmoeth
Yang Li
ResearchOpen Access07 May 2024
Nature Communications

Volume: 15, P: 1-15
Distinct immunological and molecular signatures underpinning influenza vaccine responsiveness in the elderly

Seasonal influenza vaccination is an important strategy to prevent serious disease in the elderly, but individual responsiveness to vaccination widely vary. Here authors establish, with an array of state-of-the art methods, the major immunological parameters that distinguish vaccine recipients developing robust antibody response and non-responders

Peggy Riese
Stephanie Trittel
Carlos A. Guzmán
ResearchOpen Access12 Nov 2022
Nature Communications

Volume: 13, P: 1-21
Activated protein C protects from GvHD via PAR2/PAR3 signalling in regulatory T-cells

Graft-vs.-host disease is a complication of allogenic hematopoietic stem cell transplantation, and is associated with endothelial dysfunction. Here the authors show that activated protein C signals via PAR2/PAR3 to expand T_reg cells, mitigating the disease in mice.

Satish Ranjan
Alexander Goihl
Berend Isermann
ResearchOpen Access21 Aug 2017
Nature Communications

Volume: 8, P: 1-16
Ripk1 is critical for preserving effector regulatory T cells and the suppressive transcriptional program in regulatory T cells

Carlos Plaza-Sirvent
Hannah Sturm
Ingo Schmitz
ResearchOpen Access22 Jul 2025
Cell Death & Differentiation

P: 1-14
The microbiota is dispensable for the early stages of peripheral regulatory T cell induction within mesenteric lymph nodes

Carolin Wiechers
Mangge Zou
Joern Pezoldt
ResearchOpen Access24 Mar 2021
Cellular & Molecular Immunology

Volume: 18, P: 1211-1221
Recirculating IL-1R2⁺ Tregs fine-tune intrathymic Treg development under inflammatory conditions

Eirini Nikolouli
Yassin Elfaki
Jochen Huehn
Research27 Jan 2020
Cellular & Molecular Immunology

Volume: 18, P: 182-193
Intact interleukin-10 receptor signaling protects from hippocampal damage elicited by experimental neurotropic virus infection of SJL mice

Ann-Kathrin Uhde
Malgorzata Ciurkiewicz
Andreas Beineke
ResearchOpen Access17 Apr 2018
Scientific Reports

Volume: 8, P: 1-13
Foxp3⁺ T cells expressing RORγt represent a stable regulatory T-cell effector lineage with enhanced suppressive capacity during intestinal inflammation

B-H Yang
S Hagemann
M Lochner
Research26 Aug 2015
Mucosal Immunology

Volume: 9, P: 444-457
The intestinal micro-environment imprints stromal cells to promote efficient Treg induction in gut-draining lymph nodes

S Cording
B Wahl
O Pabst
Research14 Aug 2013
Mucosal Immunology

Volume: 7, P: 359-368
De novo fatty acid synthesis controls the fate between regulatory T and T helper 17 cells

T_H17 and T_reg cell development are reciprocally regulated by de novo fatty acid synthesis, and inhibition of acetyl-CoA carboxylase 1 (ACC1) attenuates T_H17 cell–mediated autoimmune disease.

Luciana Berod
Christin Friedrich
Tim Sparwasser
Research05 Oct 2014
Nature Medicine

Volume: 20, P: 1327-1333
Efficient IL-2R signaling differentially affects the stability, function, and composition of the regulatory T-cell pool

Marc Permanyer
Berislav Bošnjak
Reinhold Förster
ResearchOpen Access06 Jan 2021
Cellular & Molecular Immunology

Volume: 18, P: 398-414
Single-cell transcriptional profiling of splenic fibroblasts reveals subset-specific innate immune signatures in homeostasis and during viral infection

Joern Pezoldt et al. analyze mouse spleen fibroblasts using single cell RNA sequencing, revealing 11 distinct clusters of fibroblastic cells or subtypes. Their results collectively provide further insight into the transcriptional identities of splenic fibroblasts and innate immune signatures of distinct stromal compartments.

Joern Pezoldt
Carolin Wiechers
Katarzyna M. Sitnik
ResearchOpen Access02 Dec 2021
Communications Biology

Volume: 4, P: 1-14
K_2P18.1 translates T cell receptor signals into thymic regulatory T cell development

Tobias Ruck
Stefanie Bock
Sven G. Meuth
ResearchOpen Access26 Oct 2021
Cell Research

Volume: 32, P: 72-88
Vitamin C supports conversion of human γδ T cells into FOXP3-expressing regulatory cells by epigenetic regulation

Léonce Kouakanou
Christian Peters
Dieter Kabelitz
ResearchOpen Access16 Apr 2020
Scientific Reports

Volume: 10, P: 1-13

Search

Epigenetic control of FOXP3 expression: the key to a stable regulatory T-cell lineage?

Postnatal expansion of mesenteric lymph node stromal cells towards reticular and CD34⁺ stromal cell subsets

Epigenetic orchestration of thymic T_reg cell development

Erratum: De novo fatty acid synthesis controls the fate between regulatory T and T helper 17 cells

DNA hypomethylation traits define human regulatory T cells in cutaneous tissue and identify their blood recirculating counterparts

Neonatally imprinted stromal cell subsets induce tolerogenic dendritic cells in mesenteric lymph nodes

A comprehensive genetic map of cytokine responses in Lyme borreliosis

Distinct immunological and molecular signatures underpinning influenza vaccine responsiveness in the elderly

Activated protein C protects from GvHD via PAR2/PAR3 signalling in regulatory T-cells

Ripk1 is critical for preserving effector regulatory T cells and the suppressive transcriptional program in regulatory T cells

The microbiota is dispensable for the early stages of peripheral regulatory T cell induction within mesenteric lymph nodes

Recirculating IL-1R2⁺ Tregs fine-tune intrathymic Treg development under inflammatory conditions

Intact interleukin-10 receptor signaling protects from hippocampal damage elicited by experimental neurotropic virus infection of SJL mice

Foxp3⁺ T cells expressing RORγt represent a stable regulatory T-cell effector lineage with enhanced suppressive capacity during intestinal inflammation

The intestinal micro-environment imprints stromal cells to promote efficient Treg induction in gut-draining lymph nodes

De novo fatty acid synthesis controls the fate between regulatory T and T helper 17 cells

Efficient IL-2R signaling differentially affects the stability, function, and composition of the regulatory T-cell pool

Single-cell transcriptional profiling of splenic fibroblasts reveals subset-specific innate immune signatures in homeostasis and during viral infection

K_2P18.1 translates T cell receptor signals into thymic regulatory T cell development

Vitamin C supports conversion of human γδ T cells into FOXP3-expressing regulatory cells by epigenetic regulation

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