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Showing 1–10 of 10 results
Advanced filters: Author: Jochen Spiegel Clear advanced filters

  • DNA G-quadruplex (G4) structures can form at regulatory regions of transcriptionally active genes in open chromatin and are abundant in cancer states, but targeting G4-binding proteins in their native chromatin environment is challenging. Now bifunctional molecules that bind naturally occurring G4 sites and recruit ubiquitination machinery facilitate the degradation of G4-specific transcription factors and chromatin remodellers.

    • Zixuan Wang
    • Xuan He
    • Shankar Balasubramanian
    ResearchOpen Access
    Nature Chemistry
    P: 1-10

  • DNA–protein interactions are essential to genome function, but they are challenging to map in a cellular environment. Now, a chemical proteomics approach, which uses DNA G-quadruplex-specific ligands containing a photocrosslinking motif, has enabled the systematic identification of DNA G-quadruplex-binding proteins in live cells.

    • Xiaoyun Zhang
    • Jochen Spiegel
    • Shankar Balasubramanian
    ResearchOpen Access
    Nature Chemistry
    Volume: 13, P: 626-633

  • Dynamic gene expression is crucial for coordinating diverse cellular activities, but challenging to modulate with high spatiotemporal precision. Now, a photoswitchable DNA structure-specific, small-molecule ligand enables reversible, light-controlled regulation of gene expression and cell proliferation in live cells.

    • Xiaoyun Zhang
    • Somdutta Dhir
    • Shankar Balasubramanian
    ResearchOpen Access
    Nature Chemistry
    Volume: 17, P: 875-882

  • Biochemical and genome-wide analyses reveal that G4 structures sequester and inhibit the activity of DNMT1, thereby protecting CpG islands from methylation in human cells.

    • Shi-Qing Mao
    • Avazeh T. Ghanbarian
    • Shankar Balasubramanian
    Research
    Nature Structural & Molecular Biology
    Volume: 25, P: 951-957

  • Bicyclic peptides can inhibit biological targets hard to address with small molecules. Here, the authors combine two orthogonal ring-closing reactions to produce bicyclic peptides with improved bioactivity thereby providing a strategy that can greatly improve the structural diversity of such peptides.

    • Philipp M. Cromm
    • Sebastian Schaubach
    • Herbert Waldmann
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-7

  • G-quadruplexes (G4s) are structures formed in guanine-rich DNA or RNA, which are linked to transcription, translation, chromatin biology, genome instability and RNA modifications. Recent studies connect G4 formation with cancer-cell lethality and indicate that G4s could be therapeutic targets.

    • Dhaval Varshney
    • Jochen Spiegel
    • Shankar Balasubramanian
    Reviews
    Nature Reviews Molecular Cell Biology
    Volume: 21, P: 459-474

  • There has been a strong effort to devise strategies to interfere with oncogenic Ras for cancer treatment. A review of recent advances in the development of small-molecule inhibitors that impair either Ras localization or protein interactions provides new optimism in this field.

    • Jochen Spiegel
    • Philipp M Cromm
    • Herbert Waldmann
    Reviews
    Nature Chemical Biology
    Volume: 10, P: 613-622

  • A multilaboratory pilot project demonstrates that hybridoma and phage display technologies can be applied to produce high-affinity, high-specificity renewable antibodies to a set of 20 human SH2 domain proteins in a reasonable time frame, suggesting that a systematic, large-scale effort to generate renewable protein binders will be feasible.

    • Karen Colwill
    • Helena Persson
    • Susanne Gräslund
    Research
    Nature Methods
    Volume: 8, P: 551-558