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Showing 1–4 of 4 results
Advanced filters: Author: Joel Mieres-Perez Clear advanced filters

  • While carbenes are versatile reactive intermediates in solution-phase organic synthesis, they have rarely been explored in on-surface synthesis. Here, the authors demonstrate the versatility of carbenes in synthesizing highly branched zero-dimensional oligomers with distinct structures on a metal surface.

    • Yunjun Cao
    • Joel Mieres-Perez
    • Karina Morgenstern
    ResearchOpen Access
    Nature Communications
    Volume: 17, P: 1-9

  • Rare mutations in the high requirement temperature protein A1 (HTRA1) cause cerebral vasculopathy. Here, authors establish mechanistically distinct protein repair approaches to reverse the deleterious effects of pathogenic mutations interfering with the assembly and protease function of HTRA1.

    • Nathalie Beaufort
    • Linda Ingendahl
    • Martin Dichgans
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-18

  • Survivin’s dual function as apoptosis inhibitor and regulator of cell proliferation is mediated via its interaction with the export receptor CRM1. Here authors report a strategy addressing its dimer interface overlapping with the nuclear export signal, the binding site of CRM1, with advanced supramolecular tweezers for lysine and arginine.

    • Annika Meiners
    • Sandra Bäcker
    • Shirley K. Knauer
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-13