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Showing 1–10 of 10 results
Advanced filters: Author: Joep Beumer Clear advanced filters

  • Rapid identification of host genes essential for virus replication may expedite the generation of therapeutic interventions. Here the authors generate mutant clonal intestinal organoids for 19 host genes previously implicated in coronavirus biology and identify the cell surface protease TMPRSS2 as a potential therapeutic target.

    • Joep Beumer
    • Maarten H. Geurts
    • Hans Clevers
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-12

  • The human endoderm-derived organoid cell atlas (HEOCA) presents an integrative analysis of single-cell transcriptomes across different conditions, sources and protocols. It compares cell types and states between models, and harmonizes cell annotations through mapping to primary tissues.

    • Quan Xu
    • Lennard Halle
    • J. Gray Camp
    ResearchOpen Access
    Nature Genetics
    Volume: 57, P: 1201-1212

  • Patient-derived intestinal organoids and tumouroids supplemented with immune cells can be used to predict and study the on-target off-tumour toxicities of T-cell-engaging bispecific antibodies and to capture inter-patient variabilities in the responses to the antibodies.

    • Marius F. Harter
    • Timothy Recaldin
    • Nikolche Gjorevski
    ResearchOpen Access
    Nature Biomedical Engineering
    Volume: 8, P: 345-360

  • Organoids derived from human intestinal cells that are co-cultured with bacteria carrying the genotoxic pks+ island develop a distinct mutational signature associated with colorectal cancer.

    • Cayetano Pleguezuelos-Manzano
    • Jens Puschhof
    • Hans Clevers
    Research
    Nature
    Volume: 580, P: 269-273

  • Currently, genetically encoded calcium indicators are not suitable for direct quantification. Here the authors engineer a fluorescence lifetime imaging calcium biosensor, Turquoise Calcium Fluorescence LIfeTime Sensor (Tq-Ca-FLITS), and measure intracellular calcium concentrations in human-derived organoids.

    • Franka H. van der Linden
    • Eike K. Mahlandt
    • Joachim Goedhart
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-13

  • This protocol describes the generation, maintenance and applications of snake venom gland organoids. These organoids can be derived within days from embryonic or adult venom gland tissues from various snake species.

    • Jens Puschhof
    • Yorick Post
    • Hans Clevers
    Protocols
    Nature Protocols
    Volume: 16, P: 1494-1510

  • This protocol comprises various methods to coculture organoids (particularly human small intestinal and colon organoids) with microbes, including microinjection into the lumen and periphery of 3D organoids and exposure of organoids to microbes in a 2D layer.

    • Jens Puschhof
    • Cayetano Pleguezuelos-Manzano
    • Hans Clevers
    Protocols
    Nature Protocols
    Volume: 16, P: 4633-4649

  • The intestinal epithelium undergoes rapid turnover and is constantly exposed to hostile luminal contents. Recent insights from single-cell transcriptomics and organoid models have revealed that tissue repair is dependent on cell lineage plasticity and signals originating from different niche components.

    • Joep Beumer
    • Hans Clevers
    Reviews
    Nature Reviews Molecular Cell Biology
    Volume: 22, P: 39-53