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An LKB1–mitochondria axis controls T_H17 effector function

OPA1 regulates the formation of the distinct mitochondrial morphology observed in T helper 17 cells, which influences cytokine expression via LKB1.

Francesc Baixauli
Klara Piletic
Erika L. Pearce
Research28 Sept 2022
Nature

Volume: 610, P: 555-561
Differentiation, ageing and leukaemia alter the metabolic profile of human bone marrow haematopoietic stem and progenitor cells

Lalioti, Romero-Mulero et al. combine metabolomics, lipidomics and transcriptomics of haematopoietic stem and progenitor cells during differentiation, ageing and leukaemia, finding a role for choline and showing that supplementation enhances stemness.

Maria-Eleni Lalioti
Mari Carmen Romero-Mulero
Nina Cabezas-Wallscheid
ResearchOpen Access15 Jul 2025
Nature Cell Biology

Volume: 27, P: 1367-1380
Microglia–neuron crosstalk through Hex–GM2–MGL2 maintains brain homeostasis

A mode of bidirectional microglia–neuron crosstalk through Hex–GM2–MGL2 and centred around GM2 ganglioside turnover is essential for homeostatic regulation of central nervous system membrane components.

Maximilian Frosch
Takashi Shimizu
Marco Prinz
ResearchOpen Access06 Aug 2025
Nature

Volume: 646, P: 913-924
Sulfur sequestration promotes multicellularity during nutrient limitation

Depriving unicellular Dictyostelium discoideum of nutrients generates reactive oxygen species that sequester cysteine within glutathione, which maintains this amoeba in a nonproliferating state that promotes aggregation into a multicellular organism.

Beth Kelly
Gustavo E. Carrizo
Erika L. Pearce
ResearchOpen Access24 Feb 2021
Nature

Volume: 591, P: 471-476
Functional multi-organelle units control inflammatory lipid metabolism of macrophages

Zimmermann et al. present OrgaPlexing, an imaging pipeline mapping metabolic organelles and their interactions. They find changes in mitochondria, ER, peroxisome and lipid droplet dynamics that impact macrophage inflammatory lipid mediator synthesis.

Julia A. Zimmermann
Kerstin Lucht
Angelika S. Rambold
ResearchOpen Access05 Jul 2024
Nature Cell Biology

Volume: 26, P: 1261-1273
Inflammatory macrophage dependence on NAD⁺ salvage is a consequence of reactive oxygen species–mediated DNA damage

Macrophages can shift their cellular metabolism in response to tissue cues and infection. Pearce and colleagues show that lipopolysaccharide-activated ‘inflammatory’ macrophages become depleted of NAD⁺ pools and require the salvage-pathway enzyme NAMPT to sustain cellular redox balance.

Alanna M. Cameron
Angela Castoldi
Edward J. Pearce
Research11 Mar 2019
Nature Immunology

Volume: 20, P: 420-432
Phosphoinositide acyl chain saturation drives CD8⁺ effector T cell signaling and function

Here the authors show how metabolic alteration of acyl chain composition affects phosphoinositide-driven signaling to initiate and sustain CD8⁺ T cell effector function during cell differentiation.

Joy Edwards-Hicks
Petya Apostolova
Erika L. Pearce
Research02 Feb 2023
Nature Immunology

Volume: 24, P: 516-530
Prostaglandin E₂ controls the metabolic adaptation of T cells to the intestinal microenvironment

CD8⁺ T cells reprogram their metabolism in response to the gut environment. Upon sensing of PGE₂, gut CD8⁺ T cells reduce their mitochondrial content, an event that ultimately shapes the pool of CD8⁺ T cells in the intestinal tissue.

Matteo Villa
David E. Sanin
Erika L. Pearce
ResearchOpen Access11 Jan 2024
Nature Communications

Volume: 15, P: 1-19
Single-cell profiling of vascular endothelial cells reveals progressive organ-specific vulnerabilities during obesity

Bondareva and Rodríguez-Aguilera et al. use scRNA-seq to analyze transcriptomes of 375,000 endothelial cells from seven organs in male mice at various stages of obesity to identify organ-specific vulnerabilities.

Olga Bondareva
Jesús Rafael Rodríguez-Aguilera
Bilal N. Sheikh
ResearchOpen Access18 Nov 2022
Nature Metabolism

Volume: 4, P: 1591-1610
Neural metabolic imbalance induced by MOF dysfunction triggers pericyte activation and breakdown of vasculature

Sheikh et al. show that deficiency in the lysine acetyltransferase MOF causes aberrant accumulation of fatty acids in neural cells, which in turn triggers inflammation in nearby pericytes, resulting in brain haemorrhaging.

Bilal N. Sheikh
Sukanya Guhathakurta
Asifa Akhtar
Research15 Jun 2020
Nature Cell Biology

Volume: 22, P: 828-841
Gut microbiota drives age-related oxidative stress and mitochondrial damage in microglia via the metabolite N⁶-carboxymethyllysine

Due to a microbiota-dependent increase in intestinal permeability with age, the gut metabolite N⁶-carboxymethyllysine accumulates in the microglia of mouse and human brains. As a result, microglia display increased oxidative stress and mitochondrial dysfunction.

Omar Mossad
Bérénice Batut
Thomas Blank
Research03 Mar 2022
Nature Neuroscience

Volume: 25, P: 295-305
Repair of airway epithelia requires metabolic rewiring towards fatty acid oxidation

Airway epithelial repair, a key process in the recovery from lung injury, requires a metabolic shift from glycolysis to fatty acid oxidation (FAO). Pharmacological FAO promotion enhances epithelial differentiation, suggesting new therapeutic options.

Stefania Crotta
Matteo Villa
Andreas Wack
ResearchOpen Access13 Feb 2023
Nature Communications

Volume: 14, P: 1-15
Metabolic conditioning of CD8⁺ effector T cells for adoptive cell therapy

Transient glucose restriction after the activation of CD8⁺ T_E cells ex vivo induces metabolic remodelling that enhances effector functions and tumour clearance in mice.

Ramon I. Klein Geltink
Joy Edwards-Hicks
Erika L. Pearce
Research03 Aug 2020
Nature Metabolism

Volume: 2, P: 703-716
A metabolic interplay coordinated by HLX regulates myeloid differentiation and AML through partly overlapping pathways

HLX transcription factor regulates haematopoietic stem and progenitor cell (HSPC) differentiation and is overexpressed in acute myeloid leukemia. Here the authors show that HLX overexpression leads to myeloid differentiation block in zebrafish and human HSPCs by direct regulation of metabolic pathways.

Indre Piragyte
Thomas Clapes
Eirini Trompouki
ResearchOpen Access06 Aug 2018
Nature Communications

Volume: 9, P: 1-17
Microbiota-dependent increase in δ-valerobetaine alters neuronal function and is responsible for age-related cognitive decline

This study shows that age-related cognitive decline is alleviated by heterochronic microbiota transplantation in mice and that δ-valerobetaine, a microbiota-derived metabolite that increases with age in both mice and humans, alters neuronal and cognitive processes.

Omar Mossad
Elisa Nent
Thomas Blank
Research20 Dec 2021
Nature Aging

Volume: 1, P: 1127-1136
TFEB induces mitochondrial itaconate synthesis to suppress bacterial growth in macrophages

The key regulator of lysosomal biogenesis, Tfeb, is shown to directly induce Irg1 transcription and mitochondrial itaconate production to restrain bacterial growth in macrophages.

Ev-Marie Schuster
Maximilian W. Epple
Angelika S. Rambold
ResearchOpen Access21 Jul 2022
Nature Metabolism

Volume: 4, P: 856-866

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