Nature Search

Homologies between gap junction proteins in lens, heart and liver

Joerg Kistler
David Christie
Stanley Bullivant
Research25 Feb 1988
Nature

Volume: 331, P: 721-723
Prostaglandin E₂ controls the metabolic adaptation of T cells to the intestinal microenvironment

CD8⁺ T cells reprogram their metabolism in response to the gut environment. Upon sensing of PGE₂, gut CD8⁺ T cells reduce their mitochondrial content, an event that ultimately shapes the pool of CD8⁺ T cells in the intestinal tissue.

Matteo Villa
David E. Sanin
Erika L. Pearce
ResearchOpen Access11 Jan 2024
Nature Communications

Volume: 15, P: 1-19
Plasmonics: Surfing the wave

Small oscillations of surface electrons that manipulate light on the nanoscale could be the route to applications as disparate as faster computer chips and cures for cancer. Joerg Heber reports.

Joerg Heber
News07 Oct 2009
Nature

Volume: 461, P: 720-722
Metabolic dependencies of metastasis-initiating cells in female breast cancer

Understanding the mechanisms associated with cancer metastasis may help control cancer progression. Here the authors investigate the metabolism of metastasis initiating cells in breast cancer and show that their metastatic ability relies on fatty acid oxidation and the oxidative tricarboxylic acid cycle, which in turn regulates acetyl-CoA generation and the acetylation of histones on EMT related genes.

C. Megan Young
Laurent Beziaud
Joerg Huelsken
ResearchOpen Access04 Nov 2023
Nature Communications

Volume: 14, P: 1-18
Microglia–neuron crosstalk through Hex–GM2–MGL2 maintains brain homeostasis

A mode of bidirectional microglia–neuron crosstalk through Hex–GM2–MGL2 and centred around GM2 ganglioside turnover is essential for homeostatic regulation of central nervous system membrane components.

Maximilian Frosch
Takashi Shimizu
Marco Prinz
ResearchOpen Access06 Aug 2025
Nature

Volume: 646, P: 913-924
Hearing of malaria mosquitoes is modulated by a beta-adrenergic-like octopamine receptor which serves as insecticide target

Malaria mosquitoes use their ears to detect the flight tones of mating partners in the swarm as part of the courtship ritual. Here, the authors describe the auditory role of octopamine as a modulator of auditory plasticity in malaria mosquitoes and identify the main receptors involved in this process.

Marcos Georgiades
Alexandros Alampounti
Marta Andrés
ResearchOpen Access19 Jul 2023
Nature Communications

Volume: 14, P: 1-20
De novo generation of hit-like molecules from gene expression signatures using artificial intelligence

High quality hit identification remains a considerable challenge in de novo drug design. Here, the authors train a generative adversarial network with transcriptome profiles induced by a large set of compounds, enabling it to design molecules that are likely to induce desired expression profiles.

Oscar Méndez-Lucio
Benoit Baillif
Joerg Wichard
ResearchOpen Access03 Jan 2020
Nature Communications

Volume: 11, P: 1-10
Sex and species specific hearing mechanisms in mosquito flagellar ears

Auditory processing is an important component of mosquito behaviour including mating. Here the authors demonstrate substantial sex- and also species-specific variation in mosquito auditory transduction, amplification and gain control.

Matthew P. Su
Marta Andrés
Joerg T. Albert
ResearchOpen Access25 Sept 2018
Nature Communications

Volume: 9, P: 1-16
Critical link between TRAIL and CCL20 for the activation of T_H2 cells and the expression of allergic airway disease

Markus Weckmann
Adam Collison
Joerg Mattes
Research14 Oct 2007
Nature Medicine

Volume: 13, P: 1308-1315
Outside-in integrin signalling regulates haematopoietic stem cell function via Periostin-Itgav axis

Integrins regulate haematopoietic stem cell (HSC) homeostasis and engraftment into the bone marrow (BM) niche upon transplantation. Here, the authors show that HSC quiescence and function in the BM is regulated by the interaction of PERIOSTIN and INTEGRIN αv and subsequent increase in p27Kip1.

Satish Khurana
Sarah Schouteden
Catherine M. Verfaillie
ResearchOpen Access01 Dec 2016
Nature Communications

Volume: 7, P: 1-14
Electric-field induced structural transition in vertical MoTe₂- and Mo_1–xW_xTe₂-based resistive memories

A vertical electric field is shown to induce reversible transitions between a semiconducting 2H phase, a distorted transient structure and a conducting T_d phase in MoTe₂ and Mo_1–xW_xTe₂ multilayers, and used to realize vertical resistive random access memories.

Feng Zhang
Huairuo Zhang
Joerg Appenzeller
Research10 Dec 2018
Nature Materials

Volume: 18, P: 55-61
A MAFG-lncRNA axis links systemic nutrient abundance to hepatic glucose metabolism

Despite widespread transcription of LncRNA in mammalian systems, their contribution to metabolic homeostasis at the cellular and tissue level remains elusive. Here Pradas-Juni et al. describe a transcription factor–LncRNA pathway that couples hepatocyte nutrient sensing to regulation of glucose metabolism in mice.

Marta Pradas-Juni
Nils R. Hansmeier
Jan-Wilhelm Kornfeld
ResearchOpen Access31 Jan 2020
Nature Communications

Volume: 11, P: 1-17
Tracing lymphopoiesis with the aid of a pTα-controlled reporter gene

Fotini Gounari
Iannis Aifantis
Boris Reizis
Research01 Apr 2002
Nature Immunology

Volume: 3, P: 489-496
Neural metabolic imbalance induced by MOF dysfunction triggers pericyte activation and breakdown of vasculature

Sheikh et al. show that deficiency in the lysine acetyltransferase MOF causes aberrant accumulation of fatty acids in neural cells, which in turn triggers inflammation in nearby pericytes, resulting in brain haemorrhaging.

Bilal N. Sheikh
Sukanya Guhathakurta
Asifa Akhtar
Research15 Jun 2020
Nature Cell Biology

Volume: 22, P: 828-841
Soundscapes and deep learning enable tracking biodiversity recovery in tropical forests

Cost-effective biodiversity monitoring through time is important for evidence-based conservation. Here, the authors show that automated bioacoustics monitoring can be used to track tropical forest recovery from agricultural abandonment, suggesting its use to assess restoration outcomes.

Jörg Müller
Oliver Mitesser
Zuzana Buřivalová
ResearchOpen Access17 Oct 2023
Nature Communications

Volume: 14, P: 1-12
Atom waves in passing

Matter-wave interferometers are unique tools for exposing particles acting like waves — one of the stranger facets of quantum theory. They can even measure the quickening of an atom's ‘pulse’ as it flies past a surface.

Maarten DeKieviet
Joerg Schmiedmayer
News & Views19 Oct 2005
Nature

Volume: 437, P: 1102
Obesity-induced overexpression of miR-802 impairs glucose metabolism through silencing of Hnf1b

The livers of obese mice and humans show increased levels of miR-802 resulting in impaired glucose tolerance and decreased insulin sensitivity through silencing of Hnf1b, revealing a novel pathway with potential relevance for type 2 diabetes.

Jan-Wilhelm Kornfeld
Catherina Baitzel
Jens C. Brüning
Research06 Feb 2013
Nature

Volume: 494, P: 111-115
Interactions between cancer stem cells and their niche govern metastatic colonization

For the initiation of metastasis, there must be a small population of cancer stem cells at the secondary site and, to maintain this population and allow proliferation, infiltrating cancer cells must induce the expression of stromal periostin.

Ilaria Malanchi
Albert Santamaria-Martínez
Joerg Huelsken
Research07 Dec 2011
Nature

Volume: 481, P: 85-89
Homeostatic maintenance and age-related functional decline in the Drosophila ear

Alyona Keder
Camille Tardieu
Joerg T. Albert
ResearchOpen Access04 May 2020
Scientific Reports

Volume: 10, P: 1-23
RANO criteria for response assessment of brain metastases based on amino acid PET imaging

The Response Assessment in Neuro-Oncology (RANO) group defines a standardized framework for amino acid PET imaging of brain metastases for use in clinical trials and eventually in clinical practice to facilitate development of novel therapies and improve patient care.

Nathalie L. Albert
Norbert Galldiks
Matthias Preusser
Reviews08 May 2025
Nature Medicine

Volume: 31, P: 1424-1430
Direct gating and mechanical integrity of Drosophila auditory transducers require TRPN1

The identity of the mechanosensitive channel responsible for sound transduction in the ear has remained elusive. Here the authors show, using interferometry, that the gating compliance of the fly's hearing organ is disrupted after deletion of TRPN1, identifying this channel as the sound transducer and/or its gating springs.

Thomas Effertz
Björn Nadrowski
Martin C Göpfert
Research29 Jul 2012
Nature Neuroscience

Volume: 15, P: 1198-1200
A combinatorial approach to the identification of self-assembled ligands for rhodium-catalysed asymmetric hydrogenation

Monodentate ligands with complementary hydrogen bonding units can self-assemble to form pseudo-bidentate ligands. Here, a combinatorial approach to the synthesis and analysis of reactions using these ligands allows the rapid identification of the most suitable ligand pair for highly selective rhodium-catalysed asymmetric hydrogenation.

Joerg Wieland
Bernhard Breit
Research22 Aug 2010
Nature Chemistry

Volume: 2, P: 832-837
Microbiota-dependent increase in δ-valerobetaine alters neuronal function and is responsible for age-related cognitive decline

This study shows that age-related cognitive decline is alleviated by heterochronic microbiota transplantation in mice and that δ-valerobetaine, a microbiota-derived metabolite that increases with age in both mice and humans, alters neuronal and cognitive processes.

Omar Mossad
Elisa Nent
Thomas Blank
Research20 Dec 2021
Nature Aging

Volume: 1, P: 1127-1136
Plant and animal functional diversity drive mutualistic network assembly across an elevational gradient

Differential responses of plant and animal functional diversity to climatic variation could affect trait matching in mutualistic interactions. Here, Albrecht et al. show that network structure varies across an elevational gradient owing to bottom-up and top-down effects of functional diversity.

Jörg Albrecht
Alice Classen
Matthias Schleuning
ResearchOpen Access09 Aug 2018
Nature Communications

Volume: 9, P: 1-10
Complement drives glucosylceramide accumulation and tissue inflammation in Gaucher disease

Complement-activating glycosylceramide-specific autoantibodies drive a self-propagating cycle of glycosylceramide accumulation and inflammation in Gaucher disease.

Manoj K. Pandey
Thomas A. Burrow
Gregory A. Grabowski
Research22 Feb 2017
Nature

Volume: 543, P: 108-112
Stepwise Evolution Improves Identification of Diverse Peptides Binding to a Protein Target

Victor I. Lyamichev
Lauren E. Goodrich
Jigar J. Patel
ResearchOpen Access21 Sept 2017
Scientific Reports

Volume: 7, P: 1-10
Observation of two-neutrino double electron capture in ¹²⁴Xe with XENON1T

Two-neutrino double electron capture is observed experimentally in ¹²⁴Xe with the XENON1T detector, yielding a half-life of 1.8 × 10²² years.

E. Aprile
J. Aalbers
J. P. Zopounidis
Research24 Apr 2019
Nature

Volume: 568, P: 532-535
Patterns of intersectional tumor volumes in T2-weighted MRI and [¹⁸F]FET PET in adult glioma: a prospective, observational study

Jonathan Weller
Marcus Unterrainer
Bogdana Suchorska
ResearchOpen Access04 Oct 2024
Scientific Reports

Volume: 14, P: 1-9
Mouse models for colorectal cancer

Joerg Heyer
Kan Yang
Raju Kucherlapati
Research20 Sept 1999
Oncogene

Volume: 18, P: 5325-5333
The effects of childhood maltreatment on epigenetic regulation of stress-response associated genes: an intergenerational approach

Laura Ramo-Fernández
Christina Boeck
Iris-Tatjana Kolassa
ResearchOpen Access18 Apr 2019
Scientific Reports

Volume: 9, P: 1-12
Synthetic two-way communication between mammalian cells

Bacchus et al. describe the first experiments in mammalian cells that distribute complex behavior across several types of engineered cells, thereby mimicking natural multicellular systems.

William Bacchus
Moritz Lang
Martin Fussenegger
Research16 Sept 2012
Nature Biotechnology

Volume: 30, P: 991-996
SecY-mediated quality control prevents the translocation of non-gated porins

Sebastian Jung
Verian Bader
Jörg Tatzelt
ResearchOpen Access01 Oct 2020
Scientific Reports

Volume: 10, P: 1-13
AI is a viable alternative to high throughput screening: a 318-target study

Izhar Wallach
Denzil Bernard
Abraham Heifets
ResearchOpen Access02 Apr 2024
Scientific Reports

Volume: 14, P: 1-16
Annexin A6 stimulates the membrane recruitment of p120GAP to modulate Ras and Raf-1 activity

Thomas Grewal
Rachael Evans
Carlos Enrich
Research06 Jun 2005
Oncogene

Volume: 24, P: 5809-5820
Author Correction: AI is a viable alternative to high throughput screening: a 318-target study

Izhar Wallach
Denzil Bernard
Ellie Giles
Amendments and CorrectionsOpen Access16 Sept 2024
Scientific Reports

Volume: 14, P: 1-2

Search

Homologies between gap junction proteins in lens, heart and liver

Prostaglandin E₂ controls the metabolic adaptation of T cells to the intestinal microenvironment

Plasmonics: Surfing the wave

Metabolic dependencies of metastasis-initiating cells in female breast cancer

Microglia–neuron crosstalk through Hex–GM2–MGL2 maintains brain homeostasis

Hearing of malaria mosquitoes is modulated by a beta-adrenergic-like octopamine receptor which serves as insecticide target

De novo generation of hit-like molecules from gene expression signatures using artificial intelligence

Sex and species specific hearing mechanisms in mosquito flagellar ears

Critical link between TRAIL and CCL20 for the activation of T_H2 cells and the expression of allergic airway disease

Outside-in integrin signalling regulates haematopoietic stem cell function via Periostin-Itgav axis

Electric-field induced structural transition in vertical MoTe₂- and Mo_1–xW_xTe₂-based resistive memories

A MAFG-lncRNA axis links systemic nutrient abundance to hepatic glucose metabolism

Tracing lymphopoiesis with the aid of a pTα-controlled reporter gene

Neural metabolic imbalance induced by MOF dysfunction triggers pericyte activation and breakdown of vasculature

Soundscapes and deep learning enable tracking biodiversity recovery in tropical forests

Atom waves in passing

Obesity-induced overexpression of miR-802 impairs glucose metabolism through silencing of Hnf1b

Interactions between cancer stem cells and their niche govern metastatic colonization

Homeostatic maintenance and age-related functional decline in the Drosophila ear

RANO criteria for response assessment of brain metastases based on amino acid PET imaging

Direct gating and mechanical integrity of Drosophila auditory transducers require TRPN1

A combinatorial approach to the identification of self-assembled ligands for rhodium-catalysed asymmetric hydrogenation

Microbiota-dependent increase in δ-valerobetaine alters neuronal function and is responsible for age-related cognitive decline

Plant and animal functional diversity drive mutualistic network assembly across an elevational gradient

Complement drives glucosylceramide accumulation and tissue inflammation in Gaucher disease

Stepwise Evolution Improves Identification of Diverse Peptides Binding to a Protein Target

Observation of two-neutrino double electron capture in ¹²⁴Xe with XENON1T

Patterns of intersectional tumor volumes in T2-weighted MRI and [¹⁸F]FET PET in adult glioma: a prospective, observational study

Mouse models for colorectal cancer

The effects of childhood maltreatment on epigenetic regulation of stress-response associated genes: an intergenerational approach

Synthetic two-way communication between mammalian cells

SecY-mediated quality control prevents the translocation of non-gated porins

AI is a viable alternative to high throughput screening: a 318-target study

Annexin A6 stimulates the membrane recruitment of p120GAP to modulate Ras and Raf-1 activity

Author Correction: AI is a viable alternative to high throughput screening: a 318-target study

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