Peptides have been known to be important therapeutics; however, minimizing purification steps, reagent expense, and reaction times in modern peptide coupling methods remains challenging. Here, the authors use sulfur(IV) fluorides as a coupling reagent, demonstrating the formation and capture of key acyl fluorosulfite intermediates for rapid peptide couplings, without epimerization or column chromatography for purification, achieving 40–94% yields for dipeptides and 24–57% yields for oligopeptide formation.
- Joey Lai
- Carlota Bahri
- Glenn M. Sammis
