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Showing 1–10 of 10 results
Advanced filters: Author: Johan Vande Voorde Clear advanced filters

  • In this Tools of the Trade article, Arafath Najumudeen and Johan Vande Voorde showcase the potential of mass spectrometry imaging for spatial metabolomics by highlighting its application in cancer, revealing metabolic differences between cell populations in the tumour microenvironment.

    • Arafath K. Najumudeen
    • Johan Vande Voorde
    Research Highlights
    Nature Reviews Genetics
    Volume: 26, P: 228

  • In this study, Vande Voorde et al. investigate the potential of untargeted metabolomics as a stratification tool for colorectal cancer (CRC). They present a comprehensive pipeline to uncover metabolic vulnerabilities in CRC based on its genetic origin. With this approach, they show perturbations in methionine metabolism linked to APC deficiency, and identify adenosylhomocysteinase as an actionable therapeutic target.

    • Johan Vande Voorde
    • Rory T. Steven
    • Owen J. Sansom
    ResearchOpen Access
    Nature Metabolism
    Volume: 5, P: 1303-1318

  • α/β-hydrolase domain-containing protein 11 (ABHD11) is a mitochondrial hydrolase, and its expression in CD4 + T-cells has been linked to remission status in rheumatoid arthritis. Here the authors report that pharmacological inhibition of ABHD11 modulates T-cell effector function via increased 24,25-epoxycholesterol biosynthesis and subsequent liver X receptor activation.

    • Benjamin J. Jenkins
    • Yasmin R. Jenkins
    • Nicholas Jones
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-18

  • Serine catabolism to formate supplies one-carbon units for biosynthesis. Here the authors show that formate production in murine cancers with high oxidative metabolism exceeds the biosynthetic demand and that high formate levels promotes invasion of cancer cells.

    • Johannes Meiser
    • Anne Schuster
    • Alexei Vazquez
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-12

  • Glutamine synthetase is the only enzyme that synthesizes glutamine in mammals. In vivo metabolomics showed that glutamine synthetase utilizes methylamine to produce N5-methylglutamine, whose levels correlate with tumor burden in a β+catenin+mutant liver cancer model.

    • Victor H. Villar
    • Maria Francesca Allega
    • Saverio Tardito
    ResearchOpen Access
    Nature Chemical Biology
    Volume: 19, P: 292-300

  • Treating malignant pleural mesothelioma (MpM) is challenging due to a lack of druggable genes, but other molecular features could be clinically useful. Here the authors profile mRNA translation dysregulation in MpM cell lines using polysome profiling, and identify mTORC1 and 2 as potential pharmacological targets.

    • Stefano Grosso
    • Alberto Marini
    • Anne E. Willis
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-17

  • This Review discusses how acetate functions as a nutritional source for tumours and as a regulator of cancer cell stress, and how preventing its (re)capture by cancer cells may provide an opportunity for therapeutic intervention.

    • Zachary T. Schug
    • Johan Vande Voorde
    • Eyal Gottlieb
    Reviews
    Nature Reviews Cancer
    Volume: 16, P: 708-717