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Showing 1–2 of 2 results
Advanced filters: Author: Johanna Heideker Clear advanced filters

  • Deubiquitinases are proteases that cleave after the C-terminus of ubiquitin to hydrolyze ubiquitin chains and cleave ubiquitin from substrates. Here the authors describe a reactive-site-centric chemoproteomics approach to studying deubiquitinase activity, and expand the repertoire of known deubiquitinases.

    • David S. Hewings
    • Johanna Heideker
    • Ingrid E. Wertz
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-17

  • The development of selective ubiquitin-specific protease-7 (USP7) inhibitors GNE-6640 and GNE-6776, which induce tumour cell death and reveal differential kinetics of Lys-48 and Lys-63-linked ubiquitin chain depolymerization by USP7.

    • Lorna Kategaya
    • Paola Di Lello
    • Ingrid E. Wertz
    Research
    Nature
    Volume: 550, P: 534-538