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Showing 1–8 of 8 results
Advanced filters: Author: Johanna Kohl Clear advanced filters

  • The Caucasus mountain range has impacted on the culture and genetics of the wider region. Here, the authors generate genome-wide SNP data for 45 Eneolithic and Bronze Age individuals across the Caucasus, and find distinct genetic clusters between mountain and steppe zones as well as occasional gene-flow.

    • Chuan-Chao Wang
    • Sabine Reinhold
    • Wolfgang Haak
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-13

  • This paper reports integrative molecular analyses of urothelial bladder carcinoma at the DNA, RNA, and protein levels performed as part of The Cancer Genome Atlas project; recurrent mutations were found in 32 genes, including those involved in cell-cycle regulation, chromatin regulation and kinase signalling pathways; chromatin regulatory genes were more frequently mutated in urothelial carcinoma than in any other common cancer studied so far.

    • John N. Weinstein
    • Rehan Akbani
    • Greg Eley
    ResearchOpen Access
    Nature
    Volume: 507, P: 315-322

  • An integrated transcriptome, genome, methylome and proteome analysis of over 200 lung adenocarcinomas reveals high rates of somatic mutations, 18 statistically significantly mutated genes including RIT1 and MGA, splicing changes, and alterations in MAPK and PI(3)K pathway activity.

    • Eric A. Collisson
    • Joshua D. Campbell
    • Ming-Sound Tsao
    ResearchOpen Access
    Nature
    Volume: 511, P: 543-550

  • Effective interfaces of knowledge and policy are critical for food system transformation. Here, an expert group assembled to explore research needs towards a safe and just food system put forward principles to guide relations between society, science, knowledge, policy and politics.

    • Jessica Duncan
    • Fabrice DeClerck
    • Gianluca Brunori
    Comments & Opinion
    Nature Food
    Volume: 3, P: 183-186

  • Non-viral vectors offer scalable, cost-effective alternatives for chimeric antigen receptor T cell therapy. In this Primer, Tretbar et al. highlight advances in the use of non-viral approaches, gene delivery methods, clinical outcomes and key considerations for translating these technologies into practice.

    • U. Sandy Tretbar
    • Joel G. Rurik
    • Ulrich Blache
    Reviews
    Nature Reviews Methods Primers
    Volume: 4, P: 1-19

  • Lisa Strug and colleagues report a genome-wide association study for meconium ileus in individuals with cystic fibrosis. Conventional genome-wide approaches identified variants in SLC26A9 and SLC6A14 associated with meconium ileus. The authors also performed a hypothesis-driven genome-wide association study (HD-GWAS) that upweighted 3,814 SNPs within 10 kb of 155 genes expressed in the apical plasma membrane. The HD-GWAS identified variants near SLC9A3 associated with meconium ileus.

    • Lei Sun
    • Johanna M Rommens
    • Lisa J Strug
    Research
    Nature Genetics
    Volume: 44, P: 562-569