Advanced search

Filter By:

Journal Check one or more journals to show results from those journals only.

Choose more journals

Article type Check one or more article types to show results from those article types only.
Subject Check one or more subjects to show results from those subjects only.
Date Choose a date option to show results from those dates only.

Custom date range

Clear all filters
Sort by:
Showing 1–4 of 4 results
Advanced filters: Author: Johannes Gregor Matthias Rack Clear advanced filters

  • PARG and ARH3 are the main hydrolases to reverse serine poly(ADP-ribosylation) yet their activities in the process differ. Here, the authors synthesise linear and branched poly(ADP-ribose) molecules, perform structure-function analysis and elucidate the mechanistic differences between PARG and ARH3.

    • Johannes Gregor Matthias Rack
    • Qiang Liu
    • Ivan Ahel
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-14

  • The pathogen Legionella pneumophila mediates NAD+-dependent ubiquitination pathways upon infection. Here, the authors show the Legionella effector MavL reverses ubiquitin ADP-ribosylation to regulate these pathways. MavL represents a new macrodomain class specific for reversal of arginine ADP-ribosylation with distinct ADP-ribose binding features.

    • Zhengrui Zhang
    • Jiaqi Fu
    • Chittaranjan Das
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-17

  • Animal models are necessary for the discovery, validation and optimization of novel therapeutics. Here, Matthias Tschöp and colleagues consolidate the key information on the currently available animal models of obesity and diabetes mellitus and highlight the advantages, limitations and important caveats of each of these models.

    • Maximilian Kleinert
    • Christoffer Clemmensen
    • Matthias H. Tschöp
    Reviews
    Nature Reviews Endocrinology
    Volume: 14, P: 140-162