Nature Search

A benchmark of expert-level academic questions to assess AI capabilities

Humanity’s Last Exam, a multi-modal benchmark at the frontier of human knowledge, is designed to be an expert-level closed-ended academic benchmark with broad subject coverage.

Long Phan
Alice Gatti
Davide Scaramuzza
ResearchOpen Access28 Jan 2026
Nature

Volume: 649, P: 1139-1146
Mapping the genetic landscape across 14 psychiatric disorders

Genomic analyses applied to 14 childhood- and adult-onset psychiatric disorders identifies five underlying genomic factors that explain the majority of the genetic variance of the individual disorders.

Andrew D. Grotzinger
Josefin Werme
Jordan W. Smoller
ResearchOpen Access10 Dec 2025
Nature

Volume: 649, P: 406-415
Evaluating the PANSS using item response theory in forensic psychiatric samples from five European nations

Andreas Wippel
Giovanni de Girolamo
Rainer W. Alexandrowicz
ResearchOpen Access25 Nov 2025
Schizophrenia

Volume: 11, P: 1-9
Identification of platelet function defects by multi-parameter assessment of thrombus formation

Platelets from patients with bleeding disorders often display altered adherence to surface proteins. In this study, de Witt et al.design a flow chamber for the systematic interrogation of platelets attaching to 52 adhesive surfaces, which may be helpful for the diagnosis of platelet disorders.

Susanne M. de Witt
Frauke Swieringa
Judith M.E.M. Cosemans
ResearchOpen Access16 Jul 2014
Nature Communications

Volume: 5, P: 1-13
A methylome-wide association study of major depression with out-of-sample case–control classification and trans-ancestry comparison

The authors report a meta-analysis of methylome-wide association studies, identifying 15 significant CpG sites linked to major depression, revealing associations with inflammatory markers and suggesting potential causal relationships through Mendelian randomization analysis.

Xueyi Shen
Miruna Barbu
Andrew M. McIntosh
ResearchOpen Access16 Sept 2025
Nature Mental Health

Volume: 3, P: 1152-1167
Reappraising consumption nudging—on liberty in the age of climate catastrophe

Oliver Braganza
Jakob Kapeller
ResearchOpen Access24 Feb 2025
Humanities and Social Sciences Communications

Volume: 12, P: 1-13
Influence of embedding media on the accuracy of working length determination by means of apex locator: an ex vivo study

Thomas Gerhard Wolf
Anna Krauß-Mironjuk
Benjamín Briseño-Marroquín
ResearchOpen Access08 Feb 2021
Scientific Reports

Volume: 11, P: 1-10
The shared frameshift mutation landscape of microsatellite-unstable cancers suggests immunoediting during tumor evolution

DNA mismatch repair (MMR)-deficient cancers with microsatellite-instability are characterized by a high load of frameshift mutation-derived neoantigens. Here, by mapping the frameshift mutation landscape and predicting the immunogenicity of the resulting peptides, the authors show evidence of immunoediting in MMR-deficient colorectal and endometrial cancers.

Alexej Ballhausen
Moritz Jakob Przybilla
Matthias Kloor
ResearchOpen Access21 Sept 2020
Nature Communications

Volume: 11, P: 1-13
DIMINISHED PULSATILE LUTEINIZING HORMONE SECRETION AND SUPERSENSITIVITY TO GONADOTROPIN RELEASING HORMONE IN AMENORRHEIC RUNNERS

Alan D Rogol
Johannes D Veldhuis
Diane Wakat
Research01 Apr 1984
Pediatric Research

Volume: 18, P: 175
Pulsatile Release of Bioactive Luteinizing Hormone in Prepubertal Girls: Discordance with Immunoreactive Luteinizing Hormone Pulses

Edward O Reiter
Darlene E Biggs
Inese Z Beitins
Research01 Apr 1987
Pediatric Research

Volume: 21, P: 409-413
Publisher Correction: Non-functional ubiquitin C-terminal hydrolase L1 drives podocyte injury through impairing proteasomes in autoimmune glomerulonephritis

Julia Reichelt
Wiebke Sachs
Catherine Meyer-Schwesinger
Amendments and CorrectionsOpen Access28 Apr 2023
Nature Communications

Volume: 14, P: 1
DNA methylation-based classification of central nervous system tumours

An online approach for the DNA methylation-based classification of central nervous system tumours across all entities and age groups has been developed to help to improve current diagnostic standards.

David Capper
David T. W. Jones
Stefan M. Pfister
Research14 Mar 2018
Nature

Volume: 555, P: 469-474
The landscape of genomic alterations across childhood cancers

Analyses of genomes from 914 children, adolescents, and young adults provide a comprehensive resource of genomic alterations across a spectrum of common childhood cancers.

Susanne N. Gröbner
Barbara C. Worst
Stefan M. Pfister
ResearchOpen Access28 Feb 2018
Nature

Volume: 555, P: 321-327
Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression

A genome-wide association meta-analysis of individuals with clinically assessed or self-reported depression identifies 44 independent risk loci. Comparisons with other psychiatric disorders and candidate gene analyses provide new insights into major depressive disorder.

Naomi R. Wray
Stephan Ripke
Patrick F. Sullivan
Research26 Apr 2018
Nature Genetics

Volume: 50, P: 668-681
Author Correction: The landscape of genomic alterations across childhood cancers

Susanne N. Gröbner
Barbara C. Worst
Stephanie Sungalee
Amendments and Corrections06 Jun 2018
Nature

Volume: 559, P: E10
Non-functional ubiquitin C-terminal hydrolase L1 drives podocyte injury through impairing proteasomes in autoimmune glomerulonephritis

In membranous nephropathy autoantibodies target podocytes of the kidney filter resulting in injury. Here the authors show that the ensuing proteostatic disturbances and proteinuria relate to aberrant interactions of non-functional UCH-L1 enzyme with the proteasome, curtailing its capacity.

Julia Reichelt
Wiebke Sachs
Catherine Meyer-Schwesinger
ResearchOpen Access13 Apr 2023
Nature Communications

Volume: 14, P: 1-19
Genome-wide association study reveals two new risk loci for bipolar disorder

Bipolar disorder (BD) is a severe mood disorder, which has been shown to have a large genetic component. Here the authors identify two previously unreported BD risk loci and provide further insights into the biological mechanisms underlying BD development.

Thomas W. Mühleisen
Markus Leber
Sven Cichon
Research11 Mar 2014
Nature Communications

Volume: 5, P: 1-8
Discovery of the first genome-wide significant risk loci for attention deficit/hyperactivity disorder

A genome-wide association study for attention deficit/hyperactivity disorder (ADHD) identifies 12 loci and implicates neurodevelopmental pathways and conserved regions of the genome as being involved in underlying ADHD biology.

Ditte Demontis
Raymond K. Walters
Benjamin M. Neale
Research26 Nov 2018
Nature Genetics

Volume: 51, P: 63-75
Confidence reports during perceptual decision making dissociate from changes in subjective experience

Using explicit measures of subjective experience and a Bayesian ordinal modeling framework, this study shows that confidence reports in perceptual decisions are influenced by nonperceptual biases.

Nicolás Sánchez-Fuenzalida
Simon van Gaal
Johannes J. Fahrenfort
ResearchOpen Access21 May 2025
Communications Psychology

Volume: 3, P: 1-11
Risk variants and polygenic architecture of disruptive behavior disorders in the context of attention-deficit/hyperactivity disorder

ADHD is often found to be comorbid with disruptive behavior disorders, but the genetic loci underlying this comorbidity are unknown. Here, the authors have performed a GWAS meta-analysis of ADHD with disruptive behavior disorders, finding three genome-wide significant loci in Europeans, and replicating one in a Chinese cohort.

Ditte Demontis
Raymond K. Walters
Anders D. Børglum
ResearchOpen Access25 Jan 2021
Nature Communications

Volume: 12, P: 1-12
A phenome-wide association and Mendelian Randomisation study of polygenic risk for depression in UK Biobank

Depression is correlated with many brain-related traits. Here, Shen et al. perform phenome-wide association studies of a depression polygenic risk score (PRS) and find associations with 51 behavioural and 26 neuroimaging traits which are further followed up on using Mendelian randomization and mediation analyses.

Xueyi Shen
David M. Howard
Andrew M. McIntosh
ResearchOpen Access08 May 2020
Nature Communications

Volume: 11, P: 1-16
Integrated analysis of environmental and genetic influences on cord blood DNA methylation in new-borns

Environmental influences during prenatal development may have implications for health and disease later in life. Here, Czamara et al. assess DNA methylation in cord blood from new-born under various models including environmental and genetic effects individually and their additive or interaction effects.

Darina Czamara
Gökçen Eraslan
Elisabeth B. Binder
ResearchOpen Access11 Jun 2019
Nature Communications

Volume: 10, P: 1-18
Psychiatric genome-wide association study analyses implicate neuronal, immune and histone pathways

Better analytical methods are needed to extract biological meaning from genome-wide association studies (GWAS) of psychiatric disorders. Here the authors take GWAS data from over 60,000 subjects, including patients with schizophrenia, bipolar disorder and major depression, and identify common etiological pathways shared amongst them.

Colm O'Dushlaine
Lizzy Rossin
Gerome Breen
Research19 Jan 2015
Nature Neuroscience

Volume: 18, P: 199-209
Orthostatic-dependent cardiopulmonary responses among trained females during intensity matched resistance exercises in a pilot randomized crossover study

Johannes Lässing
Stefan Hochstein
Roberto Falz
ResearchOpen Access23 Jun 2025
Scientific Reports

Volume: 15, P: 1-15
Identification of common genetic risk variants for autism spectrum disorder

A genome-wide-association meta-analysis of 18,381 austim spectrum disorder (ASD) cases and 27,969 controls identifies five risk loci. The authors find quantitative and qualitative polygenic heterogeneity across ASD subtypes.

Jakob Grove
Stephan Ripke
Anders D. Børglum
Research25 Feb 2019
Nature Genetics

Volume: 51, P: 431-444
Social processing distorts physical distance perception

Georgios Michalareas
Claudia Lehr
Heiko Hecht
ResearchOpen Access15 Feb 2025
Scientific Reports

Volume: 15, P: 1-17
Personalized RNA mutanome vaccines mobilize poly-specific therapeutic immunity against cancer

The authors report the first-in-human application of personalized neo-antigen RNA vaccines in patients with melanoma.

Ugur Sahin
Evelyna Derhovanessian
Özlem Türeci
Research05 Jul 2017
Nature

Volume: 547, P: 222-226
Drug sensitivity profiling of 3D tumor tissue cultures in the pediatric precision oncology program INFORM

Heike Peterziel
Nora Jamaladdin
Ina Oehme
ResearchOpen Access27 Dec 2022
npj Precision Oncology

Volume: 6, P: 1-17
A gB/CD3 bispecific BiTE antibody construct for targeting Human Cytomegalovirus-infected cells

Charlotte U. Brey
Julia Proff
Manfred Lehner
ResearchOpen Access28 Nov 2018
Scientific Reports

Volume: 8, P: 1-12
Association of polygenic score for major depression with response to lithium in patients with bipolar disorder

Azmeraw T. Amare
Klaus Oliver Schubert
Bernhard T. Baune
Research16 Mar 2020
Molecular Psychiatry

Volume: 26, P: 2457-2470
Opinion: Quantum solutions for a sustainable energy future

The technological progress made since the industrial revolution has brought with it one of our greatest challenges: how to power our world while also minimizing environmental harm. This Perspective highlights the important role that quantum chemistry has in sustainable energy research.

Johannes M. Dieterich
Emily A. Carter
Reviews05 Apr 2017
Nature Reviews Chemistry

Volume: 1, P: 1-7
Shoulder reduction on the scene: current practice and outcome of the Bavarian Mountain Rescue Service—a prospective observational study

Simon Woyke
Johannes Pawlak
Matthias Jacob
ResearchOpen Access18 Nov 2023
Scientific Reports

Volume: 13, P: 1-8
Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs

Naomi Wray and colleagues report an analysis of genome-wide association data sets from the Psychiatric Genomics Consortium for five psychiatric disorders. They find that common variation explains 17–29% of the variance in liability and provide further support for a shared genetic etiology for these related psychiatric disorders.

S Hong Lee
Stephan Ripke
Naomi R Wray
Research11 Aug 2013
Nature Genetics

Volume: 45, P: 984-994
Bipolar multiplex families have an increased burden of common risk variants for psychiatric disorders

Till F. M. Andlauer
Jose Guzman-Parra
Marcella Rietschel
ResearchOpen Access11 Nov 2019
Molecular Psychiatry

Volume: 26, P: 1286-1298
Time-to-event analysis mitigates the impact of symptomatic therapy on therapeutic benefit in Parkinson’s disease trials

Gennaro Pagano
Dylan Trundell
Stefano Zanigni
ResearchOpen Access01 Jul 2025
npj Parkinson's Disease

Volume: 11, P: 1-8
Exploratory digital outcome measures of motor sign progression in Parkinson’s disease patients treated with prasinezumab

Kirsten I. Taylor
Florian Lipsmeier
Stefano Zanigni
ResearchOpen Access16 Jun 2025
npj Digital Medicine

Volume: 8, P: 1-12
Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4

The Psychiatric GWAS Consortium Bipolar Disorder Working Group reports a large-scale genome-wide association study of 7,481 individuals with bipolar disorder with replication in 4,493 cases. The Consortium identifies a new susceptibility locus near ODZ4 and replicates a known association near CACNA1C for bipolar disorder.

Pamela Sklar
Stephan Ripke
Shaun M Purcell
Research18 Sept 2011
Nature Genetics

Volume: 43, P: 977-983
Consensus recommendations on how to assess the quality of surgical interventions

The Outcome4Medicine consensus group outline recommendations for postoperative outcome assessment, with the ultimate goal of improving care quality and patient health.

Anja Domenghino
Carmen Walbert
Claudia M. Witt
Reviews17 Apr 2023
Nature Medicine

Volume: 29, P: 811-822
The non-bilayer lipid MGDG stabilizes the major light-harvesting complex (LHCII) against unfolding

Dennis Seiwert
Hannes Witt
Harald Paulsen
ResearchOpen Access11 Jul 2017
Scientific Reports

Volume: 7, P: 1-10
Polyester degradation by soil bacteria: identification of conserved BHETase enzymes in Streptomyces

A comprehensive study on the identification and characterization of PETase-like enzymes in Streptomyces indicates the presence of strain specific variants of a conserved BHET-degrading esterase.

Jo-Anne Verschoor
Martijn R. J. Croese
Johannes H. de Winde
ResearchOpen Access12 Jun 2024
Communications Biology

Volume: 7, P: 1-13
Hair Cortisol in Twins: Heritability and Genetic Overlap with Psychological Variables and Stress-System Genes

Liz Rietschel
Fabian Streit
Marcella Rietschel
ResearchOpen Access10 Nov 2017
Scientific Reports

Volume: 7, P: 1-15
Author Correction: Risk variants and polygenic architecture of disruptive behavior disorders in the context of attention-deficit/hyperactivity disorder

Ditte Demontis
Raymond K. Walters
Anders D. Børglum
Amendments and CorrectionsOpen Access15 Feb 2021
Nature Communications

Volume: 12, P: 1
Genome-wide gene-environment analyses of major depressive disorder and reported lifetime traumatic experiences in UK Biobank

Jonathan R. I. Coleman
Wouter J. Peyrot
Gerome Breen
Research23 Jan 2020
Molecular Psychiatry

Volume: 25, P: 1430-1446
Dual role of HDAC10 in lysosomal exocytosis and DNA repair promotes neuroblastoma chemoresistance

Johannes Ridinger
Emily Koeneke
Ina Oehme
ResearchOpen Access03 Jul 2018
Scientific Reports

Volume: 8, P: 1-17
Whole-exome sequencing of 81 individuals from 27 multiply affected bipolar disorder families

Andreas J. Forstner
Sascha B. Fischer
Sven Cichon
ResearchOpen Access04 Feb 2020
Translational Psychiatry

Volume: 10, P: 1-10
A kinome-wide RNAi screen identifies ALK as a target to sensitize neuroblastoma cells for HDAC8-inhibitor treatment

Jing Shen
Sara Najafi
Ina Oehme
ResearchOpen Access07 Mar 2018
Cell Death & Differentiation

Volume: 25, P: 2053-2070
Dynamic hub load predicts cognitive decline after resective neurosurgery

Ellen W. S. Carbo
Arjan Hillebrand
Linda Douw
ResearchOpen Access07 Feb 2017
Scientific Reports

Volume: 7, P: 1-10
Tip-dated phylogeny of whirligig beetles reveals ancient lineage surviving on Madagascar

Grey T. Gustafson
Alexander A. Prokin
Kelly B. Miller
ResearchOpen Access22 Aug 2017
Scientific Reports

Volume: 7, P: 1-9
Awareness of abusive head trauma in a German population-based sample: implications for prevention

Oliver Berthold
Vera Clemens
Jörg M. Fegert
Research18 Jun 2019
Pediatric Research

Volume: 86, P: 537-541
Streptozotocin-induced β-cell damage, high fat diet, and metformin administration regulate Hes3 expression in the adult mouse brain

Polyxeni Nikolakopoulou
Antonios Chatzigeorgiou
Andreas Androutsellis-Theotokis
ResearchOpen Access27 Jul 2018
Scientific Reports

Volume: 8, P: 1-15

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