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Showing 1–13 of 13 results
Advanced filters: Author: John C. Achermann Clear advanced filters
  • Semiconductor nanocrystals seem good candidates for 'soft' optical gain media, but optical gain and lasing is hard to achieve owing to a fundamental optical effect, which involves the problem that at least two excitons need to be present in a nanocrystal to achieve gain, and this limits performance. Here the problem is circumvented by designing nanocrystals with cores and shells made from different semiconductor materials, and in such a way that electrons and holes are separated from each other: this makes possible optical gain based on single excitons, thereby significantly enhancing the promise of semiconductor nanocrystals as practical optical materials for a wide range of lasing applications.

    • Victor I. Klimov
    • Sergei A. Ivanov
    • Andrei Piryatinski
    Research
    Nature
    Volume: 447, P: 441-446
  • Disease-causing variants define a conserved and unique NR5A1 responsive enhancer for SRY expression to initiate testis-determination in humans. Modelling regulatory variants causing sex-reversal provides a tool to understand global enhancer activity.

    • Denis Houzelstein
    • Caroline Eozenou
    • Ken McElreavey
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-12
  • Transcriptomic analysis may provide information about the differentiation state and cell of origin of a cancer. Here, the authors assess mRNA signals in 1300 childhood and adult renal tumors and report a fetal origin of childhood tumors and no dedifferentiation of adult tumors.

    • Matthew D. Young
    • Thomas J. Mitchell
    • Sam Behjati
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-19
  • Time-series transcriptomic analysis investigates sex differences in human fetal brain development between 7.5 and 17 weeks post conception.

    • Federica Buonocore
    • Jenifer P. Suntharalingham
    • John C. Achermann
    ResearchOpen Access
    Communications Biology
    Volume: 8, P: 1-14
  • Here, Chow and colleagues discuss the endocrine manifestations of mitochondrial diseases, a group of multisystem disorders characterized by great clinical, biochemical and genetic heterogeneity. The authors describe the clinical features, genetic causes and pathological mechanisms underlying these diseases, the understanding of which will be key to developing innovative therapies for these patients.

    • Jasmine Chow
    • Joyeeta Rahman
    • Shamima Rahman
    Reviews
    Nature Reviews Endocrinology
    Volume: 13, P: 92-104
  • Eric Vilain and colleagues identify missense mutations in the imprinted gene CDKN1C, encoding the p57KIP2 cyclin dependent kinase inhibitor, in individuals with IMAGe syndrome. IMAGe syndrome is a developmental disorder characterized by intrauterine growth restriction, metaphyseal dysplasia, adrenal hypoplasia congenita and genital anomalies.

    • Valerie A Arboleda
    • Hane Lee
    • Eric Vilain
    Research
    Nature Genetics
    Volume: 44, P: 788-792
  • Disorders of sex development (DSDs) are caused by a broad range of genetic changes, but can be difficult to diagnose. In the past few years, advances have been made in molecular diagnostics that could affect the diagnosis of DSDs. This Review analyses the contribution of molecular biology techniques to the diagnosis and management of DSDs, as well as discussing advances in these techniques.

    • John C. Achermann
    • Sorahia Domenice
    • Berenice B. Mendonca
    Reviews
    Nature Reviews Endocrinology
    Volume: 11, P: 478-488