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Showing 1–6 of 6 results
Advanced filters: Author: John C. D’Auria Clear advanced filters

  • Tropinone is an intermediate in the biosynthesis of tropane alkaloids. Here, the authors discovered the enzymes AbPYKS and AbCYP82M3, a non-canonical polyketide synthase and a cytochrome P450, that work sequentially to form tropinone from N-methyl-Δ1-pyrrolinium cation.

    • Matthew A. Bedewitz
    • A. Daniel Jones
    • Cornelius S. Barry
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-13

  • Only a limited subset of angiosperms produce cannabinoids. Evidence for the independent evolution of cannabinoid biosynthesis was discovered in the South African plant Helichrysum umbraculigerum. This discovery provides an alternative set of enzymes that will expand the synthetic biology toolbox for those interested in manipulating the pathway for drug discovery.

    • Benjamin G. Chavez
    • John C. D’Auria
    News & Views
    Nature Plants
    Volume: 9, P: 687-688

  • Analysis of the spread of the 20E (EU1) variant of SARS-CoV-2 through Europe suggests that international travel and insufficient containment, rather than increased transmissibility, led to a resurgence of infections.

    • Emma B. Hodcroft
    • Moira Zuber
    • Richard A. Neher
    Research
    Nature
    Volume: 595, P: 707-712

  • Glucosylceramide (GlcCer), a common precursor of different glycosphingolipids, is shown to be channelled to two distinct pathways in the Golgi; non-vesicular transport from the cis- to trans-Golgi network results in the synthesis of the globo series of glycosphingolipids, whereas vesicular transport is the main source of GlcCer for ganglioside synthesis in the Golgi cisternae.

    • Giovanni D’Angelo
    • Takefumi Uemura
    • Maria Antonietta De Matteis
    Research
    Nature
    Volume: 501, P: 116-120