Advanced search

Filter By:

Journal Check one or more journals to show results from those journals only.

Choose more journals

Article type Check one or more article types to show results from those article types only.
Subject Check one or more subjects to show results from those subjects only.
Date Choose a date option to show results from those dates only.

Custom date range

Clear all filters
Sort by:
Showing 1–18 of 18 results
Advanced filters: Author: John Deanfield Clear advanced filters

  • There has been an alarming increase in the occurrence of childhood obesity, the long-term consequences of which are at least partly those of adult obesity. The direct consequences of childhood obesity on long-term cardiovascular risk, however, are less certain. Here, Peter H Whincup and John E Deanfield discuss the substantial challenges childhood obesity presents to clinicians.

    • Peter H Whincup
    • John E Deanfield
    Reviews
    Nature Clinical Practice Cardiovascular Medicine
    Volume: 2, P: 432-433

  • The Fontan palliation was introduced in 1968 for congenital heart defects with a single dominant ventricle. Although considerable technical improvements have meant that this procedure can be applied to a wide range of patients, the Fontan circulation has intrinsic limitations. Professors de Leval and Deanfield consider the past four decades of Fontan palliation and describe how developments have moved practice closer to the 'perfect' Fontan. Future challenges and possible solutions are also discussed.

    • Marc R. de Leval
    • John E. Deanfield
    Reviews
    Nature Reviews Cardiology
    Volume: 7, P: 520-527

  • Exercise is associated with reduced long-term morbidity and mortality but, in some individuals, can transiently increase the risk of fatal or nonfatal cardiac events. In this Review, Dangardt and colleagues discuss the benefits and risks of physical activity and exercise in the general population and in patients with various forms of cardiovascular disease. Strategies to promote physical activity and improve public health are proposed.

    • Frida J. Dangardt
    • William J. McKenna
    • John E. Deanfield
    Reviews
    Nature Reviews Cardiology
    Volume: 10, P: 495-507

  • In a study involving more than 100,000 individuals in the UK Biobank, a neural network model trained on metabolomic data can predict disease risk for over 20 conditions and adds predictive information over clinical variables for eight common diseases.

    • Thore Buergel
    • Jakob Steinfeldt
    • Ulf Landmesser
    ResearchOpen Access
    Nature Medicine
    Volume: 28, P: 2309-2320

  • Carotid intima-media thickness (cIMT) and plaque are associated with subclinical atherosclerosis and coronary heart disease (CHD). Here, the authors identify and prioritize genetic loci for cIMT and plaque by GWAS and colocalization approaches and further demonstrate genetic correlation with CHD and stroke.

    • Nora Franceschini
    • Claudia Giambartolomei
    • Christopher J. O’Donnell
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-14

  • Outcomes after repair of tetralogy of Fallot have been remarkably improved and short-term survival is now excellent. As patients live longer, however, late complication rates and the need for reoperation are rising. In this Review, the major complications of this heterogeneous condition are outlined and the surgical options for management discussed.

    • Tara Karamlou
    • Brian W McCrindle
    • William G Williams
    Reviews
    Nature Clinical Practice Cardiovascular Medicine
    Volume: 3, P: 611-622

  • Exome sequencing of 2,871 probands with congenital heart disease (CHD) provides new insights into the genetic architecture of these disorders. The results implicate new genes in CHD pathogenesis and highlight striking overlap between genes with damaging de novo mutations in individuals with CHD and autism.

    • Sheng Chih Jin
    • Jason Homsy
    • Martina Brueckner
    Research
    Nature Genetics
    Volume: 49, P: 1593-1601

  • Young people with type 1 diabetes mellitus (T1DM) are at risk of vascular complications. In this Perspectives article, M. Loredana Marcovecchio and colleagues present a new framework for managing the risk of vascular complications in young people with T1DM.

    • M. Loredana Marcovecchio
    • R. Neil Dalton
    • David B. Dunger
    Reviews
    Nature Reviews Endocrinology
    Volume: 15, P: 429-435

  • Exome sequencing of patients with congenital heart disease (CHD) and their unaffected parents reveals an excess of strong-effect, protein-altering de novo mutations in genes expressed in the developing heart, many of which regulate chromatin modification in key developmental genes; collectively, these mutations are predicted to account for approximately 10% of severe CHD cases.

    • Samir Zaidi
    • Murim Choi
    • Richard P. Lifton
    Research
    Nature
    Volume: 498, P: 220-223

  • Atherosclerosis refers to the accumulation of fatty and fibrous material in the arterial wall. Atherosclerotic plaques can narrow the lumen of the vessel and lead to tissue ischaemia or rupture and trigger the formation of a thrombus.

    • Peter Libby
    • Julie E. Buring
    • Eldrin F. Lewis
    Reviews
    Nature Reviews Disease Primers
    Volume: 5, P: 1-18