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Showing 101–150 of 166 results

Advanced filters: Author: John F. Hancock Clear advanced filters

Dickkopf-1 promotes hematopoietic regeneration via direct and niche-mediated mechanisms

The Wnt pathway inhibitor Dkk1, which is produced by bone marrow osteolineage cells, promotes hematopoietic recovery after radiation injury by both direct effects on hematopoietic cells and indirect effects on bone marrow endothelial cells.

Heather A Himburg
Phuong L Doan
John P Chute
Research05 Dec 2016
Nature Medicine

Volume: 23, P: 91-99
Agent-based modelling of the early stages of actin polymerisation required to drive endocytosis in Saccharomyces cerevisiae

Lewis P. Hancock
Ellen G. Allwood
Mike P. Williamson
ResearchOpen Access07 Aug 2025
Scientific Reports

Volume: 15, P: 1-14
Precise determination of the \(B_{\mathrm{s}}^0\)–\(\overline B_{\mathrm{s}}^0\) oscillation frequency

The LHCb collaboration reports an improved measurement of the oscillation frequency of mesons consisting of a bottom quark and strange quark, which is then combined with previous results.

R. Aaij
C. Abellán Beteta
G. Zunica
ResearchOpen Access06 Jan 2022
Nature Physics

Volume: 18, P: 1-5
Test of lepton universality in beauty-quark decays

The Large Hadron Collider beauty collaboration reports a test of lepton flavour universality in decays of bottom mesons into strange mesons and a charged lepton pair, finding evidence of a violation of this principle postulated in the standard model.

R. Aaij
C. Abellán Beteta
G. Zunica
ResearchOpen Access15 Mar 2022
Nature Physics

Volume: 18, P: 277-282
PA promoted to manager

Exciting new work identifies phospholipase D2 (PLD2) as an unexpected player upstream of Ras activation in epidermal growth factor (EGF)- and T-cell receptor-regulated signalling pathways. Phosphatidic acid (PA) generated on the plasma membrane by activated PLD2 directly recruits the guanine nucleotide-exchange factor Sos, or after conversion to diacylglycerol (DAG), recruits RasGRP1. These results demand a rewiring of some well-established circuit diagrams.

John F. Hancock
News & Views01 Jun 2007
Nature Cell Biology

Volume: 9, P: 615-617
Building insights into KRAS signaling complexes

The critical event in KRAS signaling and oncogenic transformation is activation of the RAF–MEK–MAPK cascade. This requires assembly of a multiprotein–lipid complex on the plasma membrane. In a tour de force of modeling, Mysore et al. now provide the first glimpse of what this structure may actually look like.

John F. Hancock
Alemayehu A. Gorfe
News & Views08 Oct 2021
Nature Structural & Molecular Biology

Volume: 28, P: 773-774
Extensive identification of genes involved in congenital and structural heart disorders and cardiomyopathy

In a multicenter research program coordinated by the International Mouse Phenotyping Consortium, Spielmann et al. analyze the cardiac function and structure in ~4,000 monogenic mutant mice and identify 705 mouse genes involved in cardiac function, 75% of which have not been previously linked to cardiac heritable disease in humans. Using the UK Biobank human data, the authors validate the link between cardiovascular disease and some of the newly identified genes to illustrate the resource value and potential of their mutant mouse collection.

Nadine Spielmann
Gregor Miller
Martin Hrabe de Angelis
ResearchOpen Access17 Feb 2022
Nature Cardiovascular Research

Volume: 1, P: 157-173
Computed tomography chest imaging offers no advantage over chest X-ray in the initial assessment of gestational trophoblastic neoplasia

Victoria L. Parker
Matthew C. Winter
Robert F. Harrison
ResearchOpen Access16 Dec 2020
British Journal of Cancer

Volume: 124, P: 1066-1071
Competitive binding of actin and SH3 domains at proline-rich regions of Las17/WASP regulates actin polymerisation

Las17/WASP is essential for actin polymerisation in yeast endocytosis. We show that SH3 domains of Sla1 compete with G-actin for binding in the Las17 polyproline region, revealing a mechanism for direct regulation of actin filament formation.

Lewis P. Hancock
John S. Palmer
Kathryn R. Ayscough
ResearchOpen Access15 May 2025
Communications Biology

Volume: 8, P: 1-16
Signalling ballet in space and time

The discovery of molecular signalling machines such as Ras nanoclusters, spatial activity gradients and flexible network circuitries involving transcriptional feedback, are beginning to reveal the design principles of spatiotemporal organization that are crucial for signalling network function and cell fate decisions.

Boris N. Kholodenko
John F. Hancock
Walter Kolch
Reviews01 Jun 2010
Nature Reviews Molecular Cell Biology

Volume: 11, P: 414-426
Induction of ornithine decarboxylase by IL-3 is mediated by sequential c-Myc-independent and c-Myc-dependent pathways

Graham Packham
John L Cleveland
Research04 Sept 1997
Oncogene

Volume: 15, P: 1219-1232
Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes

Christopher Amos and colleagues perform genome-wide association analysis for lung cancer using cohorts genotyped on the OncoArray and combing these with existing data. They identify 18 loci, 10 of which are new, finding heterogeneity across the different lung cancer subtypes, and explore candidate genes through eQTL analysis in lung tissue.

James D McKay
Rayjean J Hung
Christopher I Amos
Research12 Jun 2017
Nature Genetics

Volume: 49, P: 1126-1132
Exceptionally preserved asphaltic coprolites expand the spatiotemporal range of a North American paleoecological proxy

Alexis M. Mychajliw
Karin A. Rice
Emily L. Lindsey
ResearchOpen Access19 Mar 2020
Scientific Reports

Volume: 10, P: 1-12
On-demand manufacturing of clinical-quality biopharmaceuticals

A benchtop system for protein synthesis achieves purity and potency comparable to those of marketed drugs.

Laura E Crowell
Amos E Lu
J Christopher Love
Research01 Oct 2018
Nature Biotechnology

Volume: 36, P: 988-995
SOCS-1, a negative regulator of the JAK/STAT pathway, is silenced by methylation in human hepatocellular carcinoma and shows growth-suppression activity

Hirohide Yoshikawa
Kenichi Matsubara
James G. Herman
Research01 May 2001
Nature Genetics

Volume: 28, P: 29-35
Nasal administration of retinal antigens maintains immunosuppression of uveoretinitis in cyclosporin-a-treated lewis rats: Future treatment of endogenous posterior uveoretinitis?

Bernhard Kreutzer
Barbara Laliotou
Andrew D Dick
Research01 Jul 1997
Eye

Volume: 11, P: 445-452
The distribution and expression of the two isoforms of DNA topoisomerase II in normal and neoplastic human tissues

H Turley
M Comley
AL Harris
Research01 May 1997
British Journal of Cancer

Volume: 75, P: 1340-1346
An agonist-induced conformational change in the growth hormone receptor determines the choice of signalling pathway

Scott W. Rowlinson
Hideo Yoshizato
Michael J. Waters
Research18 May 2008
Nature Cell Biology

Volume: 10, P: 740-747
The Biologic Perturbations of Persistent Embryonic Mumps Virus Infection

Joseph W St Geme Jr.
Catherine W C Davis
Miriam A Arce
Research01 Jun 1973
Pediatric Research

Volume: 7, P: 541-552
Targeting cardiac fibrosis with engineered T cells

Adoptive transfer of CAR T cells against the fibroblast marker FAP reduces cardiac fibrosis and restores function after cardiac injury in mice, providing proof-of-principle for the development of immunotherapeutic treatments for cardiac disease.

Haig Aghajanian
Toru Kimura
Jonathan A. Epstein
Research11 Sept 2019
Nature

Volume: 573, P: 430-433
1000 Genomes-based meta-analysis identifies 10 novel loci for kidney function

Mathias Gorski
Peter J. van der Most
Christian Fuchsberger
ResearchOpen Access28 Apr 2017
Scientific Reports

Volume: 7, P: 1-11
Anti-biofilm efficacy of a medieval treatment for bacterial infection requires the combination of multiple ingredients

Jessica Furner-Pardoe
Blessing O. Anonye
Freya Harrison
ResearchOpen Access28 Jul 2020
Scientific Reports

Volume: 10, P: 1-14
Widespread shifts in the coastal biota of northern California during the 2014–2016 marine heatwaves

Eric Sanford
Jacqueline L. Sones
John L. Largier
ResearchOpen Access12 Mar 2019
Scientific Reports

Volume: 9, P: 1-14
International Standards for Neurological and Functional Classification of Spinal Cord Injury

Frederick M Maynard Jr
Michael B Bracken
Wise Young
Research01 May 1997
Spinal Cord

Volume: 35, P: 266-274
Human Proteinpedia enables sharing of human protein data

Suresh Mathivanan
Mukhtar Ahmed
Akhilesh Pandey
Correspondence01 Feb 2008
Nature Biotechnology

Volume: 26, P: 164-167
Observation of an exotic narrow doubly charmed tetraquark

The LHCb Collaboration reports the observation of an exotic, narrow, tetraquark state that contains two charm quarks, an up antiquark and a down antiquark.

R. Aaij
A. S. W. Abdelmotteleb
G. Zunica
ResearchOpen Access16 Jun 2022
Nature Physics

Volume: 18, P: 751-754
Addendum: Test of lepton universality in beauty-quark decays

R. Aaij
C. Abellán Beteta
G. Zunica
Amendments and CorrectionsOpen Access10 Aug 2023
Nature Physics

Volume: 19, P: 1517
Characterization by Electrospray Mass Spectrometry of Human Ca²⁺–sensitive Cytosolic Phospholipase A₂ Produced in Baculovirus–infected Insect Cells

Gerald W. Becker
James R. Miller
Ruth M. Kramer
Research01 Jan 1994
Bio/Technology

Volume: 12, P: 69-74
Author Correction: Potential health and economic impacts of dexamethasone treatment for patients with COVID-19

Ricardo Águas
Adam Mahdi
Mesulame Namedre
Amendments and CorrectionsOpen Access05 Mar 2021
Nature Communications

Volume: 12, P: 1
A HUPO test sample study reveals common problems in mass spectrometry–based proteomics

A multilaboratory analysis characterized the ability of 27 different labs to identify 20 proteins at equimolar concentrations in a highly purified test sample mixture using mass spectrometry. The results show that while the technology is reproducible, many common experimental problems arise, and improved search engines and databases are still needed.

Alexander W Bell
Eric W Deutsch
Juan Antonio Vizcaíno
Research17 May 2009
Nature Methods

Volume: 6, P: 423-430
Identification of genetic heterogeneity in Refsum's disease

Anthony S Wierzbicki
John Mitchell
F Brian Gibberd
Research31 Jul 2000
European Journal of Human Genetics

Volume: 8, P: 649-651
Atrial Natriuretic Peptide

John D. Baxter
John A. Lewicki
David G. Gardner
Reviews01 May 1988
Bio/Technology

Volume: 6, P: 529-546
PSICQUIC and PSISCORE: accessing and scoring molecular interactions

Bruno Aranda
Hagen Blankenburg
Henning Hermjakob
Correspondence29 Jun 2011
Nature Methods

Volume: 8, P: 528-529
Mutation of FIG4 causes neurodegeneration in the pale tremor mouse and patients with CMT4J

This manuscript provides A first description of a new spontaneous mouse mutant, called pale tremor, with a retrotransposon inserted into the gene encoding the phosphatidylinositol-3,5-bisphosphate 5-phosphatase (PtdIns(3,5)P2) Fig4. The phenotype includes early neurodegeneration, abnormal pigmentation, altered phosphoinositide levels, and the presence of large vacuoles in affected cells.

Clement Y. Chow
Yanling Zhang
Miriam H. Meisler
Research17 Jun 2007
Nature

Volume: 448, P: 68-72
Promoting coherent minimum reporting guidelines for biological and biomedical investigations: the MIBBI project

The Minimum Information for Biological and Biomedical Investigations (MIBBI) project aims to foster the coordinated development of minimum-information checklists and provide a resource for those exploring the range of extant checklists.

Chris F Taylor
Dawn Field
Stefan Wiemann
Comments & Opinion01 Aug 2008
Nature Biotechnology

Volume: 26, P: 889-896
Transgenic Expression of a Variant of Human Tissue-Type Plasminogen Activator in Goat Milk: Purification and Characterization of the Recombinant Enzyme

Julie Denman
Michael Hayes
John M. McPherson
Research01 Sept 1991
Bio/Technology

Volume: 9, P: 839-843
Comparison of weight loss data collected by research technicians versus electronic medical records: the PROPEL trial

Peter T. Katzmarzyk
Emily F. Mire
Amina D. Massey
Research06 May 2022
International Journal of Obesity

Volume: 46, P: 1456-1462
Solar abundance ratios of the iron-peak elements in the Perseus cluster

High-resolution X-ray spectra show near-solar abundances of chromium, manganese and nickel with respect to iron in the Perseus cluster, suggesting that the progenitors of type Ia supernovae could be near- and sub-Chandrasekhar-mass white dwarfs.

Felix Aharonian
Hiroki Akamatsu
Abderahmen Zoghbi
Research01 Nov 2017
Nature

Volume: 551, P: 478-480
Computational and biochemical characterization of two partially overlapping interfaces and multiple weak-affinity K-Ras dimers

Priyanka Prakash
Abdallah Sayyed-Ahmad
Alemayehu A. Gorfe
ResearchOpen Access09 Jan 2017
Scientific Reports

Volume: 7, P: 1-11
Three distinct regions of cRaf kinase domain interact with membrane

Priyanka Prakash
John F. Hancock
Alemayehu A. Gorfe
ResearchOpen Access14 Feb 2019
Scientific Reports

Volume: 9, P: 1-12
Development of in-airway laser absorption spectroscopy for respiratory based measurements of cardiac output

Nicholas M. J. Smith
John Couper
Grant A. D. Ritchie
ResearchOpen Access04 Mar 2021
Scientific Reports

Volume: 11, P: 1-13
Early risk assessment for COVID-19 patients from emergency department data using machine learning

Frank S. Heldt
Marcela P. Vizcaychipi
Rabia T. Khan
ResearchOpen Access18 Feb 2021
Scientific Reports

Volume: 11, P: 1-13
Characterization of a mutant T-cell hybridoma line with defects in the TCR-mediated apoptotic pathway

Grant Morgan
Sallie Smith
Barbara Osborne
Research11 Jan 1999
Cell Death & Differentiation

Volume: 6, P: 36-47
The minimum information about a genome sequence (MIGS) specification

Dawn Field
George Garrity
Anil Wipat
Reviews08 May 2008
Nature Biotechnology

Volume: 26, P: 541-547
Max and inhibitory c-Myc mutants induce erythroid differentiation and resistance to apoptosis in human myeloid leukemia cells

Matilde Cañelles
M Dolores Delgado
Javier León
Research20 Mar 1997
Oncogene

Volume: 14, P: 1315-1327
A multi-genotype therapeutic human papillomavirus vaccine elicits potent T cell responses to conserved regions of early proteins

Gemma Hancock
Joshua Blight
Lucy Dorrell
ResearchOpen Access10 Dec 2019
Scientific Reports

Volume: 9, P: 1-12
Publisher Correction: Extensive identification of genes involved in congenital and structural heart disorders and cardiomyopathy

Nadine Spielmann
Gregor Miller
Martin Hrabe de Angelis
Amendments and CorrectionsOpen Access20 Apr 2022
Nature Cardiovascular Research

Volume: 1, P: 529-531
PEA-15 potentiates H-Ras-mediated epithelial cell transformation through phospholipase D

F J Sulzmaier
M K G Valmiki
J W Ramos
Research21 Nov 2011
Oncogene

Volume: 31, P: 3547-3560
Therapeutic vaccination following early antiretroviral therapy elicits highly functional T cell responses against conserved HIV-1 regions

Jakub Kopycinski
Hongbing Yang
Lucy Dorrell
ResearchOpen Access11 Oct 2023
Scientific Reports

Volume: 13, P: 1-10
Quality control and quantification in IG/TR next-generation sequencing marker identification: protocols and bioinformatic functionalities by EuroClonality-NGS

Henrik Knecht
Tomas Reigl
Nikos Darzentas
ResearchOpen Access21 Jun 2019
Leukemia

Volume: 33, P: 2254-2265

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