Delivering therapeutics to the brain is challenging because of the hard-to-cross blood–brain barrier. Here, the authors show that HER3, which is expressed on the surface of many metastatic tumours, is associated with the brain endothelium and can drive accumulation of HER3-targeted nanoparticles within the brain, for therapy against HER3-positive tumours.
- Felix Alonso-Valenteen
- Simoun Mikhael
- Lali K. Medina-Kauwe
