Hellgren et al. develop AEGIS, a transcriptomics-based tool that quantifies apoptosis-linked gene signatures to assess drug-induced liver injury risk across doses, in vitro models, species, and modalities. AEGIS ranks compounds by liver risk, translates from in vitro to in vivo, and can accelerate safer drug development.
- John Hellgren
- Bhavik Chouhan
- John Gallon
