The elongation factor Elf1 functions in transcription coupled-nucleotide excision repair (TC-NER), but the mechanism by which yeast Elf1 promotes repair was unclear. Here, the authors show that Elf1 promotes TC-NER by binding TFIIH through a conserved sequence motif in its C-terminal domain.
- Kathiresan Selvam
- Jun Xu
- John J. Wyrick