Pseudouridine is the most abundant internal post-transcriptional modification of spliceosomal small nuclear RNAs and ribosomal RNAs. Transcriptome-wide maps of RNA pseudouridylation have recently established that pseudouridines are also found in mRNAs, potentially representing a new mechanism of proteomic diversification.
- John Karijolich
- Chengqi Yi
- Yi-Tao Yu