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Showing 1–9 of 9 results
Advanced filters: Author: John LaCava Clear advanced filters

  • X-ray crystallography, cryo-electron microscopy, structural modelling, biochemistry, cell biology, and evolutionary analysis enable characterization of ORF2p, the reverse transcriptase of the ancient ‘parasitic’ LINE-1 retrotransposon that has written around one-third of the human genome.

    • Eric T. Baldwin
    • Trevor van Eeuwen
    • Martin S. Taylor
    ResearchOpen Access
    Nature
    Volume: 626, P: 194-206

  • Extraction conditions can have a substantial effect on protein complexes isolated from within cells. A platform for rapid, systematic screening of these conditions is described, which should enable the identification of biologically relevant complexes.

    • Zhanna Hakhverdyan
    • Michal Domanski
    • John LaCava
    Research
    Nature Methods
    Volume: 12, P: 553-560

  • The role of Polycomb Repressive Complex 1 (PRC1) is well described in development. Here, the authors investigate canonical PRC1’s regulation of transcriptional programs in breast cancer where, in addition to its repressive function, it is also recruited to oncogenic active enhancers to regulate enhancer activity and chromatin accessibility.

    • Ho Lam Chan
    • Felipe Beckedorff
    • Lluis Morey
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-16

  • In mammals, five different CBX proteins can be part of Polycomb repressive complex 1 (PRC1). Here, the authors provide evidence that CBX6 plays an essential role in regulating pluripotency in embryonic stem cells and that CBX6 functions as part of both canonical and non-canonical PRC1 complexes.

    • Alexandra Santanach
    • Enrique Blanco
    • Luciano Di Croce
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-11

  • How the nuclear exosome is targeted to nuclear RNA substrates is poorly understood. An affinity-capture MS approach and functional analyses now demonstrate a physical and functional connection between the human exosome and the cap-binding complex (CBC). A CBC-containing complex was found to promote transcription termination of several RNA types, thus suggesting a direct link to exosomal RNA degradation.

    • Peter Refsing Andersen
    • Michal Domanski
    • Torben Heick Jensen
    Research
    Nature Structural & Molecular Biology
    Volume: 20, P: 1367-1376

  • The exosome complex of 3′→5′ exoribonucleases degrades many types of RNA in the nucleus and the cytoplasm that are targeted by the cell's RNA-surveillance machinery. It is also responsible for the precise trimming of the 3′ ends of nuclear RNA precursors during RNA maturation.

    • Jonathan Houseley
    • John LaCava
    • David Tollervey
    Reviews
    Nature Reviews Molecular Cell Biology
    Volume: 7, P: 529-539