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Showing 1–10 of 10 results
Advanced filters: Author: John Maciejowski Clear advanced filters

  • Missegregated chromosomes that are sequestrated in micronuclei are subject to changes in histone modifications leading to abnormalities in chromatin accessibility that remain long after the chromosomes have been reincorporated into the primary nucleus.

    • Albert S. Agustinus
    • Duaa Al-Rawi
    • Samuel F. Bakhoum
    ResearchOpen Access
    Nature
    Volume: 619, P: 176-183

  • Endogenous APOBEC3 deaminases generate prevalent mutational signatures in human cancer cells, and APOBEC3A is the main driver of these mutations.

    • Mia Petljak
    • Alexandra Dananberg
    • John Maciejowski
    ResearchOpen Access
    Nature
    Volume: 607, P: 799-807

  • The impact of breakage fusion bridge (BFB) cycles on tumour heterogeneity and clinical outcomes remains poorly understood. Here, the authors develop OM2BFB, an algorithm to detect and reconstruct BFB amplifications using optical genome maps and use it to study BFB events across 2557 primary tumours and cancer cell lines.

    • Siavash Raeisi Dehkordi
    • Ivy Tsz-Lo Wong
    • Vineet Bafna
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-19

  • The cytidine deaminase APOBEC3A is a main source of mutagenesis in many types of cancer. Here the authors reveal that transient up-regulation of APOBEC3A and other pro-inflammatory genes can occur due to viral infection and genotoxic stress via multiple pathways.

    • Sunwoo Oh
    • Elodie Bournique
    • Rémi Buisson
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-17

  • Gemcitabine is a widely used chemotherapy drug that acts by targeting DNA replication. Understanding why many tumors are unresponsive to gemcitabine is a clinical challenge. A new study in Nature Cancer reports that upregulation of the cytidine deaminases APOBEC3C and APOBEC3D facilitates resistance to gemcitabine by protecting cells against DNA replication stress.

    • John Maciejowski
    • Taha Mohamed
    News & Views
    Nature Cancer
    Volume: 5, P: 818-820

  • This Perspective addresses next steps to investigate the predictions that inhibition of APOBEC3-mediated mutagenesis may limit tumor heterogeneity, metastasis and drug resistance in a broad range of cancer types by highlighting gaps in our understanding of APOBEC3 biology in cancer and in healthy tissues and strategies to address them.

    • Mia Petljak
    • Abby M. Green
    • Matthew D. Weitzman
    Reviews
    Nature Genetics
    Volume: 54, P: 1599-1608

  • Telomere shortening and loss of telomere protection can have a tumour-suppressive effect by mediating proliferation arrest. Ultimately, however, these processes can cause a state of extensive genome instability known as telomere crisis, which can facilitate tumorigenesis by causing oncogenic chromosomal rearrangements, including chromothripsis, kataegis and tetraploidization.

    • John Maciejowski
    • Titia de Lange
    Reviews
    Nature Reviews Molecular Cell Biology
    Volume: 18, P: 175-186