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Advanced filters: Author: John R. Ferrarone Clear advanced filters

  • A genome-wide CRISPR screen revealed that loss of general control nonderepressible 2 (GCN2) kinase increases cellular resistance to the pan-ErbB inhibitor neratinib with neratinib directly binding and activating GCN2 kinase activity.

    • Colin P. Tang
    • Owen Clark
    • Ingo K. Mellinghoff
    Research
    Nature Chemical Biology
    Volume: 18, P: 207-215