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Persistent activation of an innate immune response translates respiratory viral infection into chronic lung disease

Edy Y Kim
John T Battaile
Michael J Holtzman
Research18 May 2008
Nature Medicine

Volume: 14, P: 633-640
Structural basis for the cooperative allosteric activation of the free fatty acid receptor GPR40

Crystal structures of hGPR40, a target for treatment of type 2 diabetes, bound to a partial and an allosteric agonist explain the binding cooperativity between these ligands and present new opportunities for structure-guided drug design.

Jun Lu
Noel Byrne
Stephen M Soisson
Research05 Jun 2017
Nature Structural & Molecular Biology

Volume: 24, P: 570-577

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Persistent activation of an innate immune response translates respiratory viral infection into chronic lung disease

Structural basis for the cooperative allosteric activation of the free fatty acid receptor GPR40

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