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Concentration and avidity of antibodies to different circumsporozoite epitopes correlate with RTS,S/AS01E malaria vaccine efficacy

RTS,S/AS01E has been tested in a phase 3 malaria vaccine trial and has shown partial efficacy in children and infants. Here, the authors analyze IgG concentration and avidity to CSP in ~1000 participants and show that IgG avidity to the C-terminus of CSP is significantly associated with vaccine-mediated protection.

Carlota Dobaño
Hèctor Sanz
Claudia Daubenberger
ResearchOpen Access15 May 2019
Nature Communications

Volume: 10, P: 1-13
Adaptation of Plasmodium falciparum to its transmission environment

A transcriptomic analysis of Plasmodium falciparum in infected children finds that parasites in areas of low transmission intensity invest more in transmission to new hosts (reproduction) and less in within-host replication (growth) than parasites in high-transmission areas.

Martin K. Rono
Mary A. Nyonda
Margaret J. Mackinnon
Research18 Dec 2017
Nature Ecology & Evolution

Volume: 2, P: 377-387
Temporal lineage replacements and dominance of imported variants of concern during the COVID-19 pandemic in Kenya

Kimita et al. detail the SARS-CoV-2 lineages present in Kenya during 5 waves of the COVID-19 pandemic between March 2020 and January 2022. Analysis of 1034 genomes identified 40 lineages, with phylogenetic analysis suggesting multiple introductions of variants from outside Kenya.

Gathii Kimita
Josphat Nyataya
John Waitumbi
ResearchOpen Access17 Aug 2022
Communications Medicine

Volume: 2, P: 1-13

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Concentration and avidity of antibodies to different circumsporozoite epitopes correlate with RTS,S/AS01E malaria vaccine efficacy

Adaptation of Plasmodium falciparum to its transmission environment

Temporal lineage replacements and dominance of imported variants of concern during the COVID-19 pandemic in Kenya

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