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Showing 1–7 of 7 results
Advanced filters: Author: John Wongvipat Clear advanced filters

  • Charles Sawyers and colleagues report that mice expressing a TMPRSS2-ERG fusion develop prostatic intraepithelial neoplasia, but only in the context of PI3-kinase pathway activation mediated by either Pten loss or Akt activation. They also find that human TMPRSS2-ERG–positive tumors are enriched for PTEN loss, suggesting that these two events cooperate in human prostate tumorigenesis.

    • Jennifer C King
    • Jin Xu
    • Charles L Sawyers
    Research
    Nature Genetics
    Volume: 41, P: 524-526

  • Although the locus at 3p13-14 is commonly deleted in prostate cancer, the identity of the potential driver genes is still unclear. Here, the authors, using a PTEN loss-driven prostate cancer mouse model, show that a multigenic FOXP1-SHQ1 deletion is a driver event with prognostic value.

    • Haley Hieronymus
    • Phillip J. Iaquinta
    • Charles L. Sawyers
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-10

  • Gastrointestinal stromal tumours (GIST) are believed to arise in interstitial cells of Cajal (ICC). These authors show that the transcription factor ETV1 is required for ICC development and promotes the development of GIST. KIT, which is often activated by mutations in GIST, cooperates with ETV1 in the transformation of ICCs, in part by promoting ETV1 stabilization. Thus, a normal developmental lineage factor is switched into a tumour-promoting factor by a cooperating oncogene.

    • Ping Chi
    • Yu Chen
    • Charles L. Sawyers
    Research
    Nature
    Volume: 467, P: 849-853

  • By exploiting the relationship between the transcription factor MYC and the transferrin receptor, where the level of transferrin receptor 1 expression may indicate activation of the MYC oncogenic pathway, Jason Holland and his colleagues have developed a novel PET radiotracer to quantitatively and noninvasively measure MYC activity. The 89Zr-desferrioxamine transferrin PET radiotracer was tested in several murine models of inflammation and MYC-driven prostate cancer.

    • Jason P Holland
    • Michael J Evans
    • Jason S Lewis
    Research
    Nature Medicine
    Volume: 18, P: 1586-1591