Dobrzycki et al delete a conserved enhancer that drives endothelial expression of the transcription factor Gata2a in Zebrafish and find that it is required for programming of haemogenic endothelium and for maintenance of haematopoietic stem cells in the adult. These data may help understanding Gata2 deficiency syndromes in humans.
- Tomasz Dobrzycki
- Christopher B. Mahony
- Rui Monteiro