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Showing 1–17 of 17 results
Advanced filters: Author: Jon Kerry Clear advanced filters
  • A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and potentially actionable mechanisms in response to infection.

    • Mari E. K. Niemi
    • Juha Karjalainen
    • Chloe Donohue
    ResearchOpen Access
    Nature
    Volume: 600, P: 472-477
  • An efficient method of cyto-swapping by haploid induction using a CENH3 mutation is reported in maize, to convert commercial germplasm to cytoplasmic male sterility for hybrid seed production.

    • Esteban Bortiri
    • Rebecca Selby
    • Tim Kelliher
    Research
    Nature Plants
    Volume: 10, P: 567-571
  • The relationship between regulatory elements, chromatin interactions and gene expression during development remains poorly understood. Here the authors present Tiled-C, a low-input 3C approach to study genome architecture at high resolution, and apply it to mouse erythroid differentiation in vivo, finding that enhancer-promoter interactions are formed gradually during differentiation, concomitant with progressive upregulation of gene activity.

    • A. Marieke Oudelaar
    • Robert A. Beagrie
    • Jim R. Hughes
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-12
  • The United Nations Decade of Ocean Science for Sustainable Development presents an exceptional opportunity to effect positive change in ocean use. We outline what is required of the deep-sea research community to achieve these ambitious objectives.

    • Kerry L. Howell
    • Ana Hilário
    • Joana R. Xavier
    Comments & Opinion
    Nature Ecology & Evolution
    Volume: 5, P: 265-267
  • The role of BRD4 and Mediator in regulating enhancer-promoter interactions is poorly understood. Here the authors find that treatment with BET inhibitors or pharmacological degradation of BRD4 disrupts transcription while having very little effect on enhancer-promoter interactions.

    • Nicholas T. Crump
    • Erica Ballabio
    • Thomas A. Milne
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-15
  • Gene fusions involving MLL and different partner genes define unique subgroups of acute myelogenous leukemia, but the mechanisms underlying specific subgroups are not fully clear. Here the authors elucidate the mechanisms of MLL-AF6 induced transformation, providing a distinct pathway that involves SHARP1 as a critical target.

    • Akihiko Numata
    • Hui Si Kwok
    • Daniel G. Tenen
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-16
  • Despite larger nonlinear coefficients, waveguide losses have prevented using semiconductors instead of dielectric materials for on-chip frequency-comb sources. By significantly reducing waveguide loss, ultra-low-threshold Kerr comb generation is demonstrated in a high-Q AlGaAs-on-insulator microresonator system.

    • Lin Chang
    • Weiqiang Xie
    • John E. Bowers
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-8
  • This mathematical modelling study projects the dynamics of SARS-CoV-2 in England until the end of 2022 assuming that the Omicron BA.2 sublineage remains dominant. They show that booster vaccination was highly effective in mitigating severe outcomes and that future dynamics will depend greatly on assumptions about waning immunity.

    • Rosanna C. Barnard
    • Nicholas G. Davies
    • W. John Edmunds
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-15
  • Parties to the Paris Agreement face mounting social pressure to raise their ambition, thereby reducing the gap between individual pledges and collective temperature goals. Although crucial for inciting positive change, especially given that the Paris Agreement lacks an enforcement mechanism, it is also important to consider social pressure’s potential negative unintended consequences. First, it might undermine the Paris Agreement’s celebrated flexibility, which allows countries to design their Nationally Determined Contributions according to domestic conditions and capabilities. Second, it might result in widespread noncompliance by inciting pledges that the countries concerned prove unwilling or even unable to fulfill. Should that happen, confidence in the Paris Agreement and its institutions might falter. Further research is therefore needed to identify the scope conditions for social pressure to work effectively in the domain of international climate policy.

    • Tatjana Stankovic
    • Jon Hovi
    • Tora Skodvin
    Comments & OpinionOpen Access
    Humanities and Social Sciences Communications
    Volume: 10, P: 1-6