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Showing 1–6 of 6 results
Advanced filters: Author: Jon R. Lorsch Clear advanced filters

  • Organizing and accessing biomedical big data will require quite different business models, say Philip E. Bourne, Jon R. Lorsch and Eric D. Green.

    • Philip E. Bourne
    • Jon R. Lorsch
    • Eric D. Green
    Comments & Opinion
    Nature
    Volume: 527, P: S16-S17

  • Eukaryotic initiation factor eIF2 binds initiator Met-tRNAiMet to the P site of the 40S ribosomal subunit. Hydroxyl radical probing analyses allowed mapping of the binding of eIF2 on the ribosome and on Met-tRNAiMet. Interestingly, despite having structural similarities to elongation factor EF-Tu, which delivers aminoacyl-tRNAs to the A site of 70S elongating ribosomes, eIF2 binds tRNA in a substantially different manner.

    • Byung-Sik Shin
    • Joo-Ran Kim
    • Thomas E Dever
    Research
    Nature Structural & Molecular Biology
    Volume: 18, P: 1227-1234

  • Translation initiation requires the formation of a pre-initiation complex that recruits the 5′ end of the mRNA and scans along it to locate the start codon. Genetic, biochemical and structural studies have shed light on the molecular mechanisms underlying the individual steps of this complex process. This Review describes our current understanding of eukaryotic translation initiation and outlines some important outstanding questions in the field.

    • Colin Echeverría Aitken
    • Jon R Lorsch
    Reviews
    Nature Structural & Molecular Biology
    Volume: 19, P: 568-576