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Showing 1–7 of 7 results
Advanced filters: Author: Jon Rink Clear advanced filters

  • Peptide drug manufacturing commonly uses large amounts of hazardous solvents primarily due to multiple washings after each step. Here, the authors introduce the concept of a completely wash-free methodology that enables up to 95% waste reduction.

    • Jonathan M. Collins
    • Sandeep K. Singh
    • Christopher L. Houser
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-11

  • It is notoriously difficult to target transcription factors with aberrant activity in cancer. Inappropriate activation of the NOTCH complex of transcription factors is directly implicated in the pathogenesis of several disease states, including T-cell acute lymphoblastic leukaemia. The design of synthetic, cell-permeable, stabilized α-helical peptides that disrupt protein–protein interactions in NOTCH is now described.

    • Raymond E. Moellering
    • Melanie Cornejo
    • James E. Bradner
    Research
    Nature
    Volume: 462, P: 182-188

  • Here the authors use mRNA display to discover peptide inhibitors of BamA, an essential factor that catalyzes the membrane insertion of bacterial outer membrane proteins. They show that three peptides are antibacterial and inhibit BamA activity by a unique mechanism.

    • Morgan E. Walker
    • Wei Zhu
    • Scott S. Walker
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-20

  • Methylome-based clustering and cross-modality integration with companion datasets from the BRAIN Initiative Cell Census Network enabled the construction of a 3D multi-omic genome atlas of the adult mouse brain featuring thousands of cell-type-specific profiles.

    • Hanqing Liu
    • Qiurui Zeng
    • Joseph R. Ecker
    ResearchOpen Access
    Nature
    Volume: 624, P: 366-377

  • This study uses epi-retro-seq to link single-cell epigenomes and cell types to long-distance projections for neurons dissected from different regions projecting to different targets across the whole mouse brain.

    • Jingtian Zhou
    • Zhuzhu Zhang
    • Edward M. Callaway
    ResearchOpen Access
    Nature
    Volume: 624, P: 355-365