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Isolation of Pure lac Operon DNA^*

JIM SHAPIRO
LORNE MACHATTIE
JON BECKWITH
Research22 Nov 1969
Nature

Volume: 224, P: 768-774
Drug-tolerant insurgents

Some cancer cells that become tolerant to a drug remain resistant even after its withdrawal, yet these cells eventually become sensitive to the drug again. The underlying molecular mechanism is unusual.

Paul Workman
Jon Travers
News & Views07 Apr 2010
Nature

Volume: 464, P: 844-845
Differential ABC transporter expression during hematopoiesis contributes to neutrophil-biased toxicity of Aurora kinase inhibitors

Patients treated with Aurora kinase inhibitors experience dose-limiting neutropenia while other cytopenias are rare. Here, Chou et al. show that this cell-type specific side effect is partly explained by loss of drug efflux pump expression during neutrophil differentiation.

David B. Chou
Brooke A. Furlong
Donald E. Ingber
ResearchOpen Access12 Oct 2022
Nature Communications

Volume: 13, P: 1-10
Drug ranking using machine learning systematically predicts the efficacy of anti-cancer drugs

Artificial intelligence and machine learning promise to transform cancer therapies by accurately predicting the most appropriate drugs to treat individual patients. Here, the authors present an approach which uses omics data to produce ordered lists of drugs based on their effectiveness in decreasing cancer cell proliferation.

Henry Gerdes
Pedro Casado
Pedro R. Cutillas
ResearchOpen Access25 Mar 2021
Nature Communications

Volume: 12, P: 1-15
Structural and functional characterization of a DARPin which inhibits Ras nucleotide exchange

Ras is mutated in many cancers, but so far no drug targeting Ras is in clinical use despite great efforts. Here the authors structurally and functionally characterize a DARPin that potently inhibits the nucleotide exchange of Ras, which might facilitate the development of Ras-targeted therapies.

Sandrine Guillard
Paulina Kolasinska-Zwierz
Ralph Minter
ResearchOpen Access14 Jul 2017
Nature Communications

Volume: 8, P: 1-11
A second update on mapping the human genetic architecture of COVID-19

Masahiro Kanai
Shea J. Andrews
Matthew Solomonson
ResearchOpen Access06 Sept 2023
Nature

Volume: 621, P: E7-E26
Targeting leukemia on the DOT

A combination of chemical and genetic approaches has established a proof of concept in mouse models—with strong mechanistic underpinning—indicating that targeting the aberrantly recruited histone methyltransferase activity of DOT1L has therapeutic potential in aggressive leukemias driven by MLL fusion genes.

Jon Travers
Julian Blagg
Paul Workman
News & Views28 Aug 2011
Nature Chemical Biology

Volume: 7, P: 663-665
Staphylococcus δ-toxin induces allergic skin disease by activating mast cells

Staphylococcus aureus δ-toxin is an inducer of mast cell degranulation in mice and is important for promoting inflammatory skin disease.

Yuumi Nakamura
Jon Oscherwitz
Gabriel Núñez
Research30 Oct 2013
Nature

Volume: 503, P: 397-401
Aurora B inhibition induces hyper-polyploidy and loss of long-term proliferative potential in RB and p53 defective cells

Shivam Vora
Saptarshi Chatterjee
Brian Gabrielli
ResearchOpen Access08 Jan 2025
Cell Death & Disease

Volume: 16, P: 1-11
Aurora B inhibitors promote RB hypophosphorylation and senescence independent of p53-dependent CDK2/4 inhibition

Shivam Vora
Ariel Andrew
Brian Gabrielli
ResearchOpen Access09 Nov 2024
Cell Death & Disease

Volume: 15, P: 1-9

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Isolation of Pure lac Operon DNA^*

Drug-tolerant insurgents

Differential ABC transporter expression during hematopoiesis contributes to neutrophil-biased toxicity of Aurora kinase inhibitors

Drug ranking using machine learning systematically predicts the efficacy of anti-cancer drugs

Structural and functional characterization of a DARPin which inhibits Ras nucleotide exchange

A second update on mapping the human genetic architecture of COVID-19

Targeting leukemia on the DOT

Staphylococcus δ-toxin induces allergic skin disease by activating mast cells

Aurora B inhibition induces hyper-polyploidy and loss of long-term proliferative potential in RB and p53 defective cells

Aurora B inhibitors promote RB hypophosphorylation and senescence independent of p53-dependent CDK2/4 inhibition

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