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Showing 1–4 of 4 results
Advanced filters: Author: Jonathan Draffin Clear advanced filters

  • How astrocytes influence neuronal plasticity remains unclear, as they are typically considered as modulators of core mechanisms driven by neuronal components. Here, authors show that Long-term depression (LTD) induction in the hippocampus triggers calcium signaling in the astrocyte and enhances SNARE-dependent astrocytic glutamate release, which is then responsible for the activation of postsynaptic NMDA receptors and synaptic depression.

    • Marta Navarrete
    • María I. Cuartero
    • José A. Esteban
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-15

  • In this study, the authors show that PTEN alters synaptic function after PDZ-dependent recruitment into spines induced by amyloid-β. This mechanism is crucial for pathogenesis, as preventing PTEN-PDZ interactions renders neurons resistant to amyloid-β and rescues cognitive function in Alzheimer's disease models. This suggests that PTEN is a critical effector of the synaptic pathology associated with Alzheimer's disease.

    • Shira Knafo
    • Cristina Sánchez-Puelles
    • José A Esteban
    Research
    Nature Neuroscience
    Volume: 19, P: 443-453