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Showing 1–7 of 7 results

Advanced filters: Author: Jonathan E. Henninger Clear advanced filters

Two Compounds implicated in the Function of the RC Gene of Escherichia coli

MICHAEL CASHEL
JONATHAN GALLANT
Research01 Mar 1969
Nature

Volume: 221, P: 838-841
Catalytic head assembling protein in virus morphogenesis

Jonathan King
Sherwood Casjens
Research13 Sept 1974
Nature

Volume: 251, P: 112-119
Clonal fate mapping quantifies the number of haematopoietic stem cells that arise during development

Henninger et al. analyse the early clonal events that underlie haematopoiesis and establish the number of stem cell clones that arise from the ventral dorsal aorta to maintain lifelong blood production.

Jonathan Henninger
Buyung Santoso
Leonard Zon
Research21 Nov 2016
Nature Cell Biology

Volume: 19, P: 17-27
Differential cofactor dependencies define distinct types of human enhancers

The systematic categorization of human enhancers by their cofactor dependencies provides a conceptual framework to understand the sequence and chromatin diversity of enhancers and their roles in different gene-regulatory programmes.

Christoph Neumayr
Vanja Haberle
Alexander Stark
Research01 Jun 2022
Nature

Volume: 606, P: 406-413
The dynamic clustering of insulin receptor underlies its signaling and is disrupted in insulin resistance

The authors find that the insulin receptor forms dynamic clusters during insulin signaling and that these clusters become dysfunctional in insulin resistance. This dysfunction is partially rescued by metformin, a drug used to treat type 2 diabetes.

Alessandra Dall’Agnese
Jesse M. Platt
Richard A. Young
ResearchOpen Access06 Dec 2022
Nature Communications

Volume: 13, P: 1-22
MeCP2 links heterochromatin condensates and neurodevelopmental disease

The chromatin protein MeCP2 is a component of dynamic, liquid-like heterochromatin condensates, and the ability of MeCP2 to form condensates is disrupted by mutations in the MECP2 gene that occur in the neurodevelopmental disorder Rett syndrome.

Charles H. Li
Eliot L. Coffey
Richard A. Young
Research22 Jul 2020
Nature

Volume: 586, P: 440-444
Pol II phosphorylation regulates a switch between transcriptional and splicing condensates

RNA polymerase II with a hypophosphorylated C-terminal domain preferentially incorporates into mediator condensates, and with a hyperphosphorylated C-terminal domain into splicing-factor condensates, revealing phosphorylation as a regulatory mechanism in condensate preference.

Yang Eric Guo
John C. Manteiga
Richard A. Young
Research07 Aug 2019
Nature

Volume: 572, P: 543-548