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Showing 1–4 of 4 results
Advanced filters: Author: Jonathan H. Esensten Clear advanced filters

  • Regulatory T cells are critically involved in immune homeostasis. Several established and experimental treatments for RA might work via effects on regulatory T cells. This Review discusses the potential benefits and pitfalls of targeting these cells to control autoimmunity.

    • Jonathan H. Esensten
    • David Wofsy
    • Jeffrey A. Bluestone
    Reviews
    Nature Reviews Rheumatology
    Volume: 5, P: 560-565

  • A non-viral strategy to introduce large DNA sequences into T cells enables the correction of a pathogenic mutation that causes autoimmunity, and the replacement of an endogenous T-cell receptor with an engineered receptor that can recognize cancer antigens.

    • Theodore L. Roth
    • Cristina Puig-Saus
    • Alexander Marson
    Research
    Nature
    Volume: 559, P: 405-409

  • Implementation of new pricing and business structures and improved licensing and manufacturing processes could reduce the per-patient cost of gene therapy tenfold.

    • Melinda Kliegman
    • Manar Zaghlula
    • Jennifer A. Doudna
    Reviews
    Nature
    Volume: 634, P: 307-314