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Showing 1–1 of 1 results
Advanced filters: Author: Jonathan P. DiNitto Clear advanced filters

  • Phosphatidylinositol-3-kinases (PI3K) γ and δ are key regulators of T cell signaling. Here the author show, using mouse heart allograft transplantation models, that PI3Kγ or PI3Kδ deficiency prolongs graft survival, but selective inhibition of PI3Kγ or PI3Kδ reveals alternative transplant survival outcomes post CTLA4-Ig treatment.

    • Mayuko Uehara
    • Martina M. McGrath
    • Reza Abdi
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-11